Reactome | IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane]

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane]

Stable Identifier

R-HSA-914169

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - 14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
      - IL3RB is phosphorylated on Ser-585 (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
      - p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)
        
        IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Homo sapiens)

Participants

components

Participates

as a component of

High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Homo sapiens)

Inferred To

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Bos taurus)

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Gallus gallus)

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Mus musculus)

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)

IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Sus scrofa)

Cross References

ComplexPortal

CPX-506