PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

Stable Identifier
R-HSA-916855
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conversion of GABA to Succinate Semialdehyde
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GABA and 2-oxoglutarate (2OG) are converted to succinate semialdehyde (SUCCSA) and L-glutamate (L-Glu) by 4 aminobutyrate aminotransferase (ABAT). The reaction takes place in the mitochondrial matrix. The active form of the enzyme is a dimer, with each subunit associated with a molecule of pyridoxal phosphate (PXLP) (De Biase et al. 1995).

Literature References
PubMed ID Title Journal Year
7851425 Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase

De Biase, D, Barra, D, Simmaco, M, John, RA, Bossa, F

Eur J Biochem 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
4-aminobutyrate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created