Reactome | ESCRT Disassembly

ESCRT Disassembly

Stable Identifier

R-HSA-917693

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

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Disassembly Phase
The AAA-ATPase, Vps4 disassembles ESCRT-III and catalyzes the final step of the MVB pathway. The microtubule interacting and trafficking (MIT) domain of Vps4 interacts directly with the C-terminal region of Vps2 (MIM1) and Vps20 (MIM2). The association of Vta1, which contains two MIT domains, greatly enhances the activity of Vps4. Please note that the recomended names of the Vacuolar protein sorting-associated proteins (Vps) are Charged multivesicular body proteins or CHMPs.

Literature References

PubMed ID	Title	Journal	Year
15075231	ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles Klumperman, J, Sachse, M, Strous, GJ	J Cell Sci	2004
11563910	Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking Abts, HF, Schöning-Burkhardt, B, Müller, S, Beyer, A, Scheuring, S, Köhrer, K, Röhricht, RA	J Mol Biol	2001