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CHMP4B [cytosol]
Stable Identifier
R-HSA-917708
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Charged multivesicular body protein 4b, CHM4B_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O95630 STAMBP
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP4B [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP4B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H444 CHMP4B
Gene Names
CHMP4B, C20orf178, SHAX1
Chain
initiator methionine:, chain:2-224
Reference Genes
BioGPS Gene:128866 CHMP4B
COSMIC (genes):CHMP4B CHMP4B
CTD Gene:128866 CHMP4B
dbSNP Gene:128866 CHMP4B
ENSEMBL:ENSG00000101421 CHMP4B
ENSEMBL_homo_sapiens_GENE:ENSG00000101421.4 CHMP4B
HGNC:16171 CHMP4B
KEGG Gene (Homo sapiens):128866 CHMP4B
Monarch:128866 CHMP4B
NCBI Gene:128866 CHMP4B
OMIM:610897 CHMP4B
UCSC:Q9H444 CHMP4B
Reference Transcript
RefSeq:NM_176812.4 CHMP4B
Other Identifiers
11716496_s_at
11716497_at
128866
16912871
225119_PM_at
225119_at
225498_PM_at
225498_at
3536837
3536838
3882682
3882683
3882684
3882685
3882686
3882702
3882703
3882704
3882705
3882707
3882708
3882709
3882710
45298_at
77390_at
8061958
80658_at
A_23_P28969
A_23_P301732
GE86533
GO:0000278
GO:0000281
GO:0000421
GO:0000776
GO:0000815
GO:0000910
GO:0001778
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005643
GO:0005694
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005771
GO:0005773
GO:0005828
GO:0005829
GO:0005856
GO:0005886
GO:0006620
GO:0006886
GO:0006900
GO:0006914
GO:0006997
GO:0007010
GO:0007034
GO:0007040
GO:0007059
GO:0007080
GO:0009898
GO:0010008
GO:0010458
GO:0010506
GO:0010824
GO:0015031
GO:0016020
GO:0016192
GO:0016236
GO:0030117
GO:0030163
GO:0030496
GO:0031410
GO:0031468
GO:0031902
GO:0031982
GO:0032511
GO:0032585
GO:0036258
GO:0036438
GO:0039702
GO:0042060
GO:0042802
GO:0042803
GO:0043162
GO:0043226
GO:0045296
GO:0046755
GO:0046761
GO:0050877
GO:0051258
GO:0051469
GO:0061024
GO:0061763
GO:0061952
GO:0065003
GO:0070062
GO:0071985
GO:0090148
GO:0090611
GO:0097352
GO:0140014
GO:1901673
GO:1902774
GO:1904930
HMNXSV003058445
Hs.164478.2.S1_3p_at
Hs.178137.2.S1_3p_at
ILMN_1771233
PH_hs_0024600
PH_hs_0040162
TC20000235.hg
Participates
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as a member of
CHMP4 [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP4B [endosome membrane]
Inferred To
chmp4c [cytosol]
(Danio rerio)
snf7 [cytosol]
(Schizosaccharomyces pombe)
SNF7 [cytosol]
(Saccharomyces cerevisiae)
chmp4 [cytosol]
(Dictyostelium discoideum)
vps-32.1 [cytosol]
(Caenorhabditis elegans)
chmp4b [cytosol]
(Xenopus tropicalis)
Homologues of CHMP4B [cytosol]
(Caenorhabditis elegans)
Homologues of CHMP4B [cytosol]
(Schizosaccharomyces pombe)
CHMP4B [cytosol]
(Bos taurus)
CHMP4B [cytosol]
(Caenorhabditis elegans)
CHMP4B [cytosol]
(Canis familiaris)
CHMP4B [cytosol]
(Gallus gallus)
CHMP4B [cytosol]
(Sus scrofa)
chmp-7 [cytosol]
(Caenorhabditis elegans)
shrb [cytosol]
(Drosophila melanogaster)
Chmp4b [cytosol]
(Mus musculus)
Chmp4b [cytosol]
(Rattus norvegicus)
cmp7 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_789782.1
OpenTargets
ENSG00000101421
GeneCards
Q9H444
HPA
ENSG00000101421-CHMP4B
Ensembl
ENST00000217402
,
ENSP00000217402
,
ENSG00000101421
PRO
Q9H444
Pharos - Targets
Q9H444
Orphanet
16864
PDB
3C3Q
,
4ABM
,
3UM3
,
5MK2
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.864
6
UniProt:Q9Y3E7 CHMP3
2
CHMP3 [cytosol]
(R-HSA-917722)
CHMP3 [endosome membrane]
(R-HSA-9631191)
0.693
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:Q6P1N0 C2D1A
0.659
4
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.658
4
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.642
7
UniProt:Q5VW32 BROX
0.611
5
UniProt:Q9UQN3 CHMP2B
2
CHMP2B [endosome membrane]
(R-HSA-9631179)
CHMP2B [cytosol]
(R-HSA-917695)
0.59
2
UniProt:O43633 CHMP2A
2
CHMP2A [cytosol]
(R-HSA-917734)
CHMP2A [endosome membrane]
(R-HSA-9631172)
0.59
3
UniProt:O60664 PLIN3
7
p-PLIN3 [lysosomal lumen]
(R-HSA-9639396)
p-PLIN3 [cytosol]
(R-HSA-9613664)
p-PLIN3 [lipid droplet]
(R-HSA-9613539)
PLIN3 [lipid droplet]
(R-HSA-9613337)
p-PLIN3 [late endosome lumen]
(R-HSA-9639393)
PLIN3 [cytosol]
(R-HSA-6814628)
PLIN3 [transport vesicle]
(R-HSA-6813900)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q9BY43-2 CHMP4A
0.556
3
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.553
3
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.553
3
UniProt:Q7LBR1 CHM1B
0.547
2
UniProt:Q9NZZ3 CHMP5
1
CHMP5 [cytosol]
(R-HSA-917694)
0.547
4
UniProt:Q96FZ7 CHMP6
2
CHMP6 [endosome membrane]
(R-HSA-9631195)
CHMP6 [cytosol]
(R-HSA-917736)
0.547
2
UniProt:Q96CF2 CHMP4C
2
CHMP4C [endosome membrane]
(R-HSA-9631186)
CHMP4C [cytosol]
(R-HSA-917710)
0.547
2
UniProt:Q8WUX9 CHMP7
2
CHMP7 [cytosol]
(R-HSA-917703)
CHMP7 [endosome membrane]
(R-HSA-9631168)
0.543
3
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
5
UniProt:Q96SN8 CDK5RAP2
1
CDK5RAP2 [cytosol]
(R-HSA-380282)
0.527
3
UniProt:P38606 ATP6V1A
1
ATP6V1A [cytosol]
(R-HSA-912602)
0.527
2
UniProt:Q9WU78-1 PDCD6IP
0.522
2
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