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PDCD6IP [cytosol]
Stable Identifier
R-HSA-917717
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ALIX, Programmed cell death 6-interacting protein, PDC6I_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
PDCD6IP [cytosol] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
PDCD6IP [cytosol] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
PDCD6IP [cytosol] (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol) (Homo sapiens)
PDCD6IP [cytosol] (Homo sapiens)
PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol) (Homo sapiens)
PDCD6IP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WUM4 PDCD6IP
Gene Names
PDCD6IP, AIP1, ALIX, KIAA1375
Chain
initiator methionine:1, chain:2-868
Reference Genes
BioGPS Gene:10015 PDCD6IP
COSMIC (genes):PDCD6IP PDCD6IP
CTD Gene:10015 PDCD6IP
dbSNP Gene:10015 PDCD6IP
ENSEMBL:ENSG00000170248 PDCD6IP
ENSEMBL_homo_sapiens_GENE:ENSG00000170248 PDCD6IP
HGNC:8766 PDCD6IP
KEGG Gene (Homo sapiens):10015 PDCD6IP
Monarch:10015 PDCD6IP
NCBI Gene:10015 PDCD6IP
OMIM:608074 PDCD6IP
UCSC:Q8WUM4 PDCD6IP
Reference Transcript
RefSeq:NM_001162429.2 PDCD6IP
RefSeq:NM_001256192.1 PDCD6IP
RefSeq:NM_013374.5 PDCD6IP
Other Identifiers
0001780278
10015
11716144_a_at
11716145_a_at
11905
16212
16938763
17121250
17121252
217746_s_at
222394_at
2616332
2616333
2616337
2616340
2616344
2616345
2616346
2616352
2616356
2616357
2616358
2616359
2616360
2616363
2616364
2616366
2616373
2616374
2616375
2616376
2616377
2616378
2OEV
2OEW
2OEX
2OJQ
2R02
2R03
2R05
2XS1
2XS8
2ZNE
3585877
3585881
3585883
3585886
3613381
3613382
3613383
3613385
3613386
3613388
3613389
3C3O
3C3Q
3C3R
3E1R
3WUV
44185_at
4JJY
54133_at
5V3R
5WA1
65980_at
8078479
A0A3B3IT07
A_14_P111655
A_14_P201549
A_23_P60816
A_24_P63118
A_24_P945194
A_32_P22338
AAF08220
AAH20066
AAH68454
AAK20398
AAP36031
AB037796
AC112220
AC123901
ACS12984
AF151793
AF349951
AK002122
BAA92092
BAA92613
BC020066
BC068454
BT007367
C9IZF9
CAB016212
CCDS2660
CCDS54561
ENSG00000170248
ENSP00000307387
ENSP00000411825
ENST00000307296
ENST00000307296.7
ENST00000457054
ENST00000457054.6
EntrezGene:10015
F8WBR8
F8WDK9
F8WEQ7
g7019486_3p_a_at
GE53935
GE81831
GO:0000281
GO:0000915
GO:0001772
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005923
GO:0005925
GO:0006810
GO:0006915
GO:0007010
GO:0007049
GO:0008150
GO:0008219
GO:0010824
GO:0015031
GO:0016020
GO:0016032
GO:0019058
GO:0022607
GO:0030054
GO:0031410
GO:0031871
GO:0034330
GO:0036258
GO:0039702
GO:0042470
GO:0042641
GO:0042803
GO:0043226
GO:0044403
GO:0045199
GO:0046755
GO:0046983
GO:0048306
GO:0051260
GO:0051301
GO:0061024
GO:0061952
GO:0065003
GO:0070062
GO:0070830
GO:0070971
GO:0090543
GO:0090559
GO:0090611
GO:1903543
GO:1903551
GO:1903553
GO:1903561
GQ131806
HGNC:8766
HPA011905
Hs.9663.0.S2_3p_at
Hs.9663.0.S2_3p_x_at
ILMN_1693259
ILMN_2111323
IPR004328
IPR025304
IPR038499
MIM:608074
NM_001162429
NM_013374
NP_001155901
NP_037506
PDCD6IP
PDCD6IP-201
PDCD6IP-206
PF03097
PF13949
PH_hs_0030975
SM01041
TC03000168.hg
TC03002277.hg
TC03002278.hg
UPI00000709A6
UPI00004121D3
XM_011533252
XM_011533253
XM_017005488
XP_011531554
XP_011531555
XP_016860977
Participant Of
hasComponent
Virion Budding Complex [plasma membrane]
input
Recruitment Of HIV Virion Budding Machinery
This entity regulates
Positively
PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol)
PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)
Cross References
RefSeq
NP_037506.2
,
NP_001243121.1
,
NP_001155901.1
OpenTargets
ENSG00000170248
GeneCards
Q8WUM4
PRO
Q8WUM4
HMDB Protein
HMDBP07936
PDB
3WUV
,
4JJY
,
3E1R
,
5WA1
,
2OEX
,
2R02
,
2R03
,
3C3R
,
2XS8
,
2OJQ
,
2ZNE
,
3C3Q
,
2OEV
,
2R05
,
2XS1
,
5V3R
,
2OEW
,
3C3O
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.864
6
UniProt:Q53EZ4 CEP55
0.858
14
UniProt:O75340 PDCD6
0.826
11
UniProt:P08631 HCK
1
HCK [cytosol]
(R-HSA-167708)
0.709
4
UniProt:Q9BY43 CHMP4A
2
CHMP4A [cytosol]
(R-HSA-917733)
CHMP4A [endosome membrane]
(R-HSA-9631184)
0.683
3
UniProt:P06241 FYN
6
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-Y420-FYN [cytosol]
(R-HSA-391821)
FYN [cytosol]
(R-HSA-200917)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
0.671
6
UniProt:Q96CF2 CHMP4C
2
CHMP4C [cytosol]
(R-HSA-917710)
CHMP4C [endosome membrane]
(R-HSA-9631186)
0.667
3
UniProt:P12931 SRC
6
p-Y416-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.653
7
UniProt:Q90VU7 Q90VU7
0.593
4
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.591
3
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [cytosol]
(R-HSA-182957)
SH3KBP1 [plasma membrane]
(R-HSA-182955)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.591
5
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.573
3
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.573
3
UniProt:P09022 Hoxa1
1
Hoxa1 [nucleoplasm]
(R-MMU-5617924)
0.57
3
UniProt:Q9D8B3
2
CHMP4B [cytosol]
(R-MMU-917708)
CHMP4B [endosome membrane]
(R-MMU-9631202)
0.564
2
IntAct:EBI-15674727 P6GAGT
0.558
2
IntAct:EBI-15674662 P6GAGA
0.558
2
IntAct:EBI-15674685 P9GAG
0.558
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.553
2
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [plasma membrane]
(R-HSA-879445)
0.527
2
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
0.499
2
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