Reactome | PDCD6IP [cytosol]

PDCD6IP [cytosol]

Stable Identifier

R-HSA-917717

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ALIX, Programmed cell death 6-interacting protein, PDC6I_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8WUM4 PDCD6IP

Gene Names

PDCD6IP, AIP1, ALIX, KIAA1375

Chain

initiator methionine:1, chain:2-868

Reference Genes

BioGPS Gene:10015 PDCD6IP

COSMIC (genes):PDCD6IP PDCD6IP

CTD Gene:10015 PDCD6IP

dbSNP Gene:10015 PDCD6IP

ENSEMBL:ENSG00000170248 PDCD6IP

HGNC:8766 PDCD6IP

KEGG Gene (Homo sapiens):10015 PDCD6IP

Monarch:10015 PDCD6IP

NCBI Gene:10015 PDCD6IP

OMIM:608074 PDCD6IP

UCSC:Q8WUM4 PDCD6IP

Reference Transcript

Other Identifiers

0001780278

10015

11716144_a_at

11716145_a_at

16938763

17121250

17121252

217746_s_at

222394_at

2616331

2616332

2616333

2616337

2616340

2616344

2616345

2616346

2616352

2616356

2616357

2616358

2616359

2616360

2616363

2616364

2616366

2616373

2616374

2616375

2616376

2616377

2616378

3585877

3585881

3585883

3585886

3613381

3613382

3613383

3613385

3613386

3613388

3613389

44185_at

54133_at

65980_at

8078479

A_14_P111655

A_14_P201549

A_23_P60816

A_24_P63118

A_24_P945194

A_32_P22338

GE53935

GE81831

GO:0000278

GO:0000281

GO:0000915

GO:0001772

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005923

GO:0005925

GO:0006810

GO:0006915

GO:0007010

GO:0007049

GO:0008150

GO:0008219

GO:0009056

GO:0010824

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0019058

GO:0022607

GO:0030054

GO:0031410

GO:0031871

GO:0034330

GO:0036258

GO:0039702

GO:0042470

GO:0042641

GO:0042803

GO:0043226

GO:0043231

GO:0044403

GO:0045199

GO:0046755

GO:0048306

GO:0051260

GO:0051301

GO:0061024

GO:0061952

GO:0065003

GO:0070062

GO:0070830

GO:0070971

GO:0090543

GO:0090559

GO:0090611

GO:1903543

GO:1903551

GO:1903553

GO:1903561

Hs.9663.0.S2_3p_at

Hs.9663.0.S2_3p_x_at

ILMN_1693259

ILMN_2111323

PH_hs_0030975

TC03000168.hg

TC03002277.hg

TC03002278.hg

g7019486_3p_a_at

Participant Of

hasComponent

input

This entity regulates

Positively

Inferred To

pdcd6ip [cytosol] (Danio rerio)

Pdcd6ip [cytosol] (Mus musculus)

Pdcd6ip [cytosol] (Rattus norvegicus)

PDCD6IP [cytosol] (Bos taurus)

PDCD6IP [cytosol] (Sus scrofa)

alxA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_037506.2, NP_001155901.1, NP_001243121.1

OpenTargets

ENSG00000170248

GeneCards

Q8WUM4

HPA

ENSG00000170248-PDCD6IP

Ensembl

ENSP00000411825, ENST00000307296, ENSP00000307387, ENSG00000170248, ENST00000457054

PRO

Q8WUM4

HMDB Protein

HMDBP07936

PDB

3C3O, 2OEV, 2XS1, 2OEW, 5WA1, 5V3R, 2R05, 3E1R, 4JJY, 3C3R, 2XS8, 2OEX, 2R02, 3WUV, 2OJQ, 2R03, 3C3Q, 2ZNE

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53EZ4 CEP55			0.893	16
UniProt:O75340 PDCD6			0.867	12
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.864	6
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.709	4
UniProt:Q9BY43 CHMP4A	2	CHMP4A [cytosol] (R-HSA-917733) CHMP4A [endosome membrane] (R-HSA-9631184)	0.683	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.681	4
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.671	6
UniProt:Q96CF2 CHMP4C	2	CHMP4C [cytosol] (R-HSA-917710) CHMP4C [endosome membrane] (R-HSA-9631186)	0.667	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.653	7
UniProt:Q90VU7 Q90VU7			0.593	4
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.591	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [cytosol] (R-HSA-182957) SH3KBP1 [plasma membrane] (R-HSA-182955) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.591	5
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.573	3
UniProt:P09022 Hoxa1	1	Hoxa1 [nucleoplasm] (R-MMU-5617924)	0.57	3
UniProt:Q9D8B3 Chmp4b	2	Chmp4b [cytosol] (R-MMU-917708) Chmp4b [endosome membrane] (R-MMU-9631199)	0.564	2
IntAct:EBI-15674727 P6GAGT			0.558	2
IntAct:EBI-15674662 P6GAGA			0.558	2
IntAct:EBI-15674685 P9GAG			0.558	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.553	2
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [plasma membrane] (R-HSA-879445)	0.527	2
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [cytosol] (R-HSA-5205676) MAP1LC3A [autophagosome membrane] (R-HSA-5683640)	0.499	2

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