Reactome | CHMP3 [cytosol]

CHMP3 [cytosol]

Stable Identifier

R-HSA-917722

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

VPS24, Charged multivesicular body protein 3, CHMP3_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O43633 CHMP2A

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External Reference Information

External Reference

UniProt:Q9Y3E7 CHMP3

Gene Names

CHMP3, CGI149, NEDF, VPS24, CGI-149

Chain

initiator methionine:, chain:2-222

Reference Genes

BioGPS Gene:100526767 CHMP3

BioGPS Gene:51652 CHMP3

COSMIC (genes):CHMP3 CHMP3

CTD Gene:100526767 CHMP3

CTD Gene:51652 CHMP3

dbSNP Gene:100526767 CHMP3

dbSNP Gene:51652 CHMP3

ENSEMBL:ENSG00000115561 CHMP3

HGNC:29865 CHMP3

KEGG:hsa:100526767 CHMP3

KEGG:hsa:51652 CHMP3

Monarch:100526767 CHMP3

Monarch:51652 CHMP3

NCBI Gene:100526767 CHMP3

NCBI Gene:51652 CHMP3

OMIM:610052 CHMP3

UCSC:Q9Y3E7 CHMP3

Reference Transcript

Participates

as an output of

as an input of

CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)

as a component of

ESCRT-III [cytosol] (Homo sapiens)

Other forms of this molecule

CHMP3 [endosome membrane]

Inferred To

Chmp3 [cytosol] (Mus musculus)

Chmp3 [cytosol] (Rattus norvegicus)

CHMP3 [cytosol] (Bos taurus)

CHMP3 [cytosol] (Canis familiaris)

CHMP3 [cytosol] (Gallus gallus)

CHMP3 [cytosol] (Sus scrofa)

chmp3 [cytosol] (Danio rerio)

chmp3 [cytosol] (Dictyostelium discoideum)

chmp3 [cytosol] (Xenopus tropicalis)

VPS24 [cytosol] (Saccharomyces cerevisiae)

Vps24 [cytosol] (Drosophila melanogaster)

vps-24 [cytosol] (Caenorhabditis elegans)

vps24 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001180446.1, NP_001005753.1, NP_057163.1, NP_001185883.1

OpenTargets

ENSG00000115561

ENSEMBL

ENSG00000115561, ENST00000409225, ENSP00000386590, ENSP00000263856, ENSP00000387045, ENST00000263856, ENST00000409727

HPA

ENSG00000115561-CHMP3

GeneCards

CHMP3

PRO

Q9Y3E7

Pharos - Targets

Q9Y3E7

PDB

3FRV, 7ZCG, 2GD5, 2XZE, 7ZCH, 3FRT

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.964	27
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.693	5
UniProt:O43633 CHMP2A	2	CHMP2A [cytosol] (R-HSA-917734) CHMP2A [endosome membrane] (R-HSA-9631172)	0.667	3
UniProt:Q9UQN3 CHMP2B	2	CHMP2B [endosome membrane] (R-HSA-9631179) CHMP2B [cytosol] (R-HSA-917695)	0.592	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	3
UniProt:Q9NPC8 SIX2	1	SIX2 [nucleoplasm] (R-HSA-9831037)	0.527	2
UniProt:Q7L2J0 MEPCE			0.527	2
UniProt:Q9H5V9 STEEP1	1	STEEP1 [nucleoplasm] (R-HSA-9769596)	0.527	2
UniProt:Q9NZZ3 CHMP5	1	CHMP5 [cytosol] (R-HSA-917694)	0.527	2
UniProt:Q9UIW0 VAX2			0.527	2

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