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CHMP3 [cytosol]
Stable Identifier
R-HSA-917722
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
VPS24, Charged multivesicular body protein 3, CHMP3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O95630 STAMBP
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP3 [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP3 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
ESCRT Disassembly (Homo sapiens)
CHMP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3E7 CHMP3
Gene Names
CHMP3, CGI149, NEDF, VPS24, CGI-149
Chain
initiator methionine:, chain:2-222
Reference Genes
BioGPS Gene:100526767 CHMP3
BioGPS Gene:51652 CHMP3
COSMIC (genes):CHMP3 CHMP3
CTD Gene:100526767 CHMP3
CTD Gene:51652 CHMP3
dbSNP Gene:100526767 CHMP3
dbSNP Gene:51652 CHMP3
ENSEMBL:ENSG00000115561 CHMP3
ENSEMBL_homo_sapiens_GENE:ENSG00000115561.16 CHMP3
HGNC:29865 CHMP3
KEGG Gene (Homo sapiens):100526767 CHMP3
KEGG Gene (Homo sapiens):51652 CHMP3
Monarch:100526767 CHMP3
Monarch:51652 CHMP3
NCBI Gene:100526767 CHMP3
NCBI Gene:51652 CHMP3
OMIM:610052 CHMP3
UCSC:Q9Y3E7 CHMP3
Reference Transcript
RefSeq:NM_001198954.1 CHMP3
RefSeq:NM_016079.3 CHMP3
RefSeq:NM_001005753.2 CHMP3
RefSeq:NM_001193517.1 CHMP3
Other Identifiers
11717424_x_at
11717425_a_at
11717426_a_at
217837_PM_s_at
217837_s_at
222436_PM_s_at
222436_s_at
222437_PM_s_at
222437_s_at
2562820
2562822
2562823
2562824
2562825
2562826
2562829
2562831
2562832
2562840
2562841
2562851
2562858
2562859
3652462
49383_at
51652
8053562
A_23_P79510
A_24_P240065
A_33_P3316639
GE88124
GO:0000278
GO:0000421
GO:0000776
GO:0000815
GO:0000910
GO:0001778
GO:0005515
GO:0005546
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005643
GO:0005694
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005773
GO:0005828
GO:0005829
GO:0005856
GO:0005886
GO:0006914
GO:0006915
GO:0006997
GO:0007010
GO:0007034
GO:0007040
GO:0007049
GO:0007059
GO:0007080
GO:0008289
GO:0008333
GO:0010824
GO:0012501
GO:0015031
GO:0016020
GO:0016192
GO:0016236
GO:0019076
GO:0030163
GO:0030496
GO:0031210
GO:0031410
GO:0031468
GO:0031902
GO:0032467
GO:0032509
GO:0032585
GO:0036258
GO:0039702
GO:0042060
GO:0042802
GO:0043162
GO:0043226
GO:0044790
GO:0045324
GO:0046761
GO:0051036
GO:0051258
GO:0051301
GO:0051469
GO:0061024
GO:0061763
GO:0061952
GO:0065003
GO:0070062
GO:0071985
GO:0090148
GO:0097352
GO:0098542
GO:0098772
GO:0140014
GO:0140678
GO:1901673
GO:1902774
GO:1904930
GO:1990381
GO:2000641
HMNXSV003034238
Hs.189658.0.S1_3p_a_at
ILMN_1683827
ILMN_1743505
ILMN_2406043
PH_hs_0026770
PH_hs_0039950
TC02004385.hg
TC02005035.hg
g13325201_3p_a_at
g7706352_3p_a_at
g7706352_3p_x_at
Participates
as an output of
ESCRT Disassembly (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as a component of
ESCRT-III [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP3 [endosome membrane]
Inferred To
Chmp3 [cytosol]
(Mus musculus)
Chmp3 [cytosol]
(Rattus norvegicus)
CHMP3 [cytosol]
(Bos taurus)
CHMP3 [cytosol]
(Canis familiaris)
CHMP3 [cytosol]
(Gallus gallus)
CHMP3 [cytosol]
(Sus scrofa)
chmp3 [cytosol]
(Danio rerio)
chmp3 [cytosol]
(Dictyostelium discoideum)
chmp3 [cytosol]
(Xenopus tropicalis)
VPS24 [cytosol]
(Saccharomyces cerevisiae)
Vps24 [cytosol]
(Drosophila melanogaster)
vps-24 [cytosol]
(Caenorhabditis elegans)
vps24 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_057163.1
,
NP_001005753.1
,
NP_001180446.1
,
NP_001185883.1
OpenTargets
ENSG00000115561
HPA
ENSG00000115561-CHMP3
GeneCards
Q9Y3E7
Ensembl
ENST00000409727
,
ENSP00000386590
,
ENSG00000115561
,
ENSP00000387045
,
ENSP00000263856
,
ENST00000263856
,
ENST00000409225
PRO
Q9Y3E7
Pharos - Targets
Q9Y3E7
PDB
3FRT
,
2XZE
,
7ZCG
,
2GD5
,
3FRV
,
7ZCH
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.964
27
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.693
5
UniProt:O43633 CHMP2A
2
CHMP2A [cytosol]
(R-HSA-917734)
CHMP2A [endosome membrane]
(R-HSA-9631172)
0.667
3
UniProt:Q9UQN3 CHMP2B
2
CHMP2B [endosome membrane]
(R-HSA-9631179)
CHMP2B [cytosol]
(R-HSA-917695)
0.592
2
UniProt:Q9UIW0 VAX2
0.527
2
UniProt:Q9NZZ3 CHMP5
1
CHMP5 [cytosol]
(R-HSA-917694)
0.527
2
UniProt:Q9H5V9 STEEP1
1
STEEP1 [nucleoplasm]
(R-HSA-9769596)
0.527
2
UniProt:Q7L2J0 MEPCE
0.527
2
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.527
3
UniProt:Q9NPC8 SIX2
1
SIX2 [nucleoplasm]
(R-HSA-9831037)
0.527
2
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