Reactome | TSG101 [cytosol]

TSG101 [cytosol]

Stable Identifier

R-HSA-917727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tumor susceptibility gene 101 protein, TS101_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8NEZ2 VPS37A

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External Reference Information

External Reference

UniProt:Q99816 TSG101

Gene Names

TSG101

Chain

initiator methionine:1, chain:2-390

Reference Genes

BioGPS Gene:7251 TSG101

COSMIC (genes):TSG101 TSG101

CTD Gene:7251 TSG101

dbSNP Gene:7251 TSG101

ENSEMBL:ENSG00000074319 TSG101

HGNC:15971 TSG101

KEGG:hsa:7251 TSG101

Monarch:7251 TSG101

NCBI Gene:7251 TSG101

OMIM:601387 TSG101

UCSC:Q99816 TSG101

Reference Transcript

RefSeq:NM_006292.4 TSG101

This entity regulates

Positively

DENV virion buds into ER lumen (Homo sapiens)

Other forms of this molecule

TSG101 [endosome membrane]

Cross References

RefSeq

NP_006283.1

OpenTargets

ENSG00000074319

ENSEMBL

ENST00000251968, ENSG00000074319, ENSP00000251968

GeneCards

TSG101

HPA

ENSG00000074319-TSG101

ZINC - Substances

TS101_HUMAN

ZINC target

Q99816

PRO

Q99816

Pharos - Targets

Q99816

GlyGen

Q99816

PDB

6VME, 1KPQ, 1KPP, 1M4P, 1M4Q, 7ZLX, 3OBU, 5VKG, 7NLC, 3OBS, 3P9H, 4YC1, 4EJE, 2F0R, 3P9G, 6UD0, 4ZNY, 3OBQ, 3OBX, 1S1Q, 3IV1

Interactors (70)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53EZ4 CEP55			0.967	26
UniProt:Q9UK41 VPS28	1	VPS28 [endosome membrane] (R-HSA-184342)	0.939	15
UniProt:Q8NEZ2 VPS37A	1	VPS37A [endosome membrane] (R-HSA-184333)	0.845	9
UniProt:Q6UWE0 LRSAM1	1	LRSAM1 [cytosol] (R-HSA-976004)	0.83	8
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.785	6
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.782	7
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.782	10
UniProt:O60291 MGRN1	1	MGRN1 [cytosol] (R-HSA-975971)	0.754	5
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.742	5
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.718	6
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.718	6
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.718	6
UniProt:P18095 GAG			0.71	11
UniProt:Q99LI8	1	Hgs [cytosol] (R-MMU-182954)	0.683	5
UniProt:Q96IF1 AJUBA	3	AJUBA [cytosol] (R-HSA-2564698) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [nucleoplasm] (R-HSA-5687935)	0.683	4
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.666	5
UniProt:Q9UK41-2 VPS28			0.666	6
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.666	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.643	4
UniProt:Q8NEZ2-2 VPS37A			0.638	5
UniProt:P28290 ITPI2			0.623	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.609	2
UniProt:O75674 TM1L1			0.592	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.581	5
UniProt:Q8BT07 CEP55			0.564	2
UniProt:Q99732 LITAF			0.558	3
UniProt:Q8WU39 MZB1			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q8N7C3 TRIMM			0.556	3
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:O95295 SNAPIN	2	SNAPIN [Golgi membrane] (R-HSA-434344) SNAPIN [cytoplasmic vesicle membrane] (R-HSA-434204)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q8TC20-4 CAGE1			0.556	3
UniProt:Q96JZ2 HSH2D			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q9BQ89 F110A			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q9ULD4-2 Q9ULD42			0.556	3
UniProt:Q6ZMJ2-2 SCARA5			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.556	3
UniProt:O95678 KRT75	1	KRT75 [cytosol] (R-HSA-6809652)	0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	5
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.556	3
IntAct:EBI-22312375 CCSB ORF ID			0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	5
UniProt:Q8N5I2 ARRD1			0.527	3
UniProt:Q9NZ09 UBAP1	1	UBAP1 [endosome membrane] (R-HSA-8955361)	0.527	3
UniProt:O60939 SCN2B	1	SCN2B [plasma membrane] (R-HSA-197905)	0.527	2
UniProt:P21453 S1PR1	1	S1PR1 [plasma membrane] (R-HSA-419340)	0.527	2
UniProt:Q86XT2 VPS37D	1	VPS37D [endosome membrane] (R-HSA-184289)	0.527	3
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.508	2
UniProt:Q13464 ROCK1	6	ROCK1 [extracellular region] (R-HSA-6806527) ROCK1 [secretory granule lumen] (R-HSA-6804967) Activated ROCK1 [cytosol] (R-HSA-4687777) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) ROCK1 [cytosol] (R-HSA-212509)	0.508	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.499	2
UniProt:Q93062-3 RBPMS			0.488	2

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