Reactome | VPS4A [cytosol]

VPS4A [cytosol]

Stable Identifier

R-HSA-917732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vacuolar protein sorting-associated protein 4A, VPS4A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96K21 ANCHR

Expand all

External Reference Information

External Reference

UniProt:Q9UN37 VPS4A

Gene Names

VPS4A, VPS4

Chain

chain:1-437

Reference Genes

BioGPS Gene:27183 VPS4A

COSMIC (genes):VPS4A VPS4A

CTD Gene:27183 VPS4A

dbSNP Gene:27183 VPS4A

ENSEMBL:ENSG00000132612 VPS4A

HGNC:13488 VPS4A

KEGG:hsa:27183 VPS4A

Monarch:27183 VPS4A

NCBI Gene:27183 VPS4A

OMIM:609982 VPS4A

UCSC:Q9UN37 VPS4A

Reference Transcript

RefSeq:NM_013245.2 VPS4A

Other Identifiers

11745333_a_at

16820572

217913_PM_at

217913_at

27183

3666648

3666650

3666651

3666652

3666653

3666657

3666659

3666660

3666661

3666662

3666663

3666664

3666665

3666666

3666667

3666668

3666669

3666670

3666671

3666673

3666674

3666675

3666676

3666677

3666678

3666679

3666682

3666683

44787_s_at

45802_at

57935_at

70639_at

7996919

A_14_P114896

A_14_P114928

A_23_P329772

GE62753

GO:0000910

GO:0000916

GO:0000922

GO:0001778

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005643

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005774

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005886

GO:0006622

GO:0006886

GO:0006900

GO:0006914

GO:0006997

GO:0006998

GO:0007032

GO:0007033

GO:0007080

GO:0007084

GO:0009838

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016236

GO:0016787

GO:0016887

GO:0019076

GO:0030496

GO:0031410

GO:0031468

GO:0031902

GO:0032367

GO:0032466

GO:0032880

GO:0034058

GO:0036258

GO:0039702

GO:0043162

GO:0043226

GO:0044877

GO:0044878

GO:0046761

GO:0048471

GO:0051301

GO:0061024

GO:0061640

GO:0061738

GO:0061764

GO:0061952

GO:0070062

GO:0071985

GO:0072319

GO:0090148

GO:0090543

GO:0090611

GO:0097352

GO:0140545

GO:0140657

GO:1903076

GO:1903543

GO:1903774

GO:1904896

GO:1904903

GO:1904949

HMNXSV003051082

ILMN_1708946

PH_hs_0026702

TC16000567.hg

g7019568_3p_at

Participates

as a component of

as an input of

as an output of

Inferred To

Vps4 [cytosol] (Drosophila melanogaster)

vps-4 [cytosol] (Caenorhabditis elegans)

VPS4A [cytosol] (Bos taurus)

VPS4A [cytosol] (Canis familiaris)

VPS4A [cytosol] (Dictyostelium discoideum)

VPS4A [cytosol] (Gallus gallus)

VPS4A [cytosol] (Mus musculus)

VPS4A [cytosol] (Rattus norvegicus)

VPS4A [cytosol] (Saccharomyces cerevisiae)

VPS4A [cytosol] (Schizosaccharomyces pombe)

VPS4A [cytosol] (Sus scrofa)

vps4a [cytosol] (Danio rerio)

vps4a [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_037377.1

ENSEMBL

ENST00000254950, ENSP00000254950

OpenTargets

ENSG00000132612

IntEnz

3.6.4.6

HPA

ENSG00000132612-VPS4A

PRO

Q9UN37

Pharos - Targets

Q9UN37

GlyGen

Q9UN37

HMDB Protein

HMDBP12005

PDB

1YXR, 2JQ9, 2K3W

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.788	9
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.659	8
UniProt:Q7LBR1 CHM1B			0.592	4
UniProt:Q9HD42-1 CHMP1A			0.558	2
UniProt:O95833 CLIC3			0.556	3
UniProt:O43633 CHMP2A	2	CHMP2A [cytosol] (R-HSA-917734) CHMP2A [endosome membrane] (R-HSA-9631172)	0.547	4
UniProt:Q96K21 ANCHR			0.527	2
UniProt:O75351 VPS4B	1	VPS4B [cytosol] (R-HSA-917719)	0.527	3
UniProt:Q9NP79 VTA1	1	VTA1 [cytosol] (R-HSA-917735)	0.527	2
UniProt:P53990 IST1	3	IST1 [extracellular region] (R-HSA-6806231) IST1 [azurophil granule lumen] (R-HSA-6799169) IST1 [cytosol] (R-HSA-9668516)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3

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