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VPS4A [cytosol]
Stable Identifier
R-HSA-917732
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Vacuolar protein sorting-associated protein 4A, VPS4A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9NP79 VTA1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
VPS4A [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
VPS4A [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
HCMV Final Envelopment (Homo sapiens)
VPS4A [cytosol] (Homo sapiens)
HCMV Formation of Final Envelopment Complex (Homo sapiens)
VPS4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UN37 VPS4A
Gene Names
VPS4A, VPS4
Chain
chain:1-437
Reference Genes
BioGPS Gene:27183 VPS4A
COSMIC (genes):VPS4A VPS4A
CTD Gene:27183 VPS4A
dbSNP Gene:27183 VPS4A
ENSEMBL:ENSG00000132612 VPS4A
ENSEMBL_homo_sapiens_GENE:ENSG00000132612.16 VPS4A
HGNC:13488 VPS4A
KEGG Gene (Homo sapiens):27183 VPS4A
Monarch:27183 VPS4A
NCBI Gene:27183 VPS4A
OMIM:609982 VPS4A
UCSC:Q9UN37 VPS4A
Reference Transcript
RefSeq:NM_013245.2 VPS4A
Other Identifiers
11745333_a_at
16820572
217913_PM_at
217913_at
27183
3666650
3666651
3666652
3666657
3666659
3666660
3666661
3666662
3666663
3666664
3666665
3666667
3666669
3666673
3666674
3666675
3666676
3666677
3666678
3666679
3666682
3666683
44787_s_at
45802_at
57935_at
70639_at
7996919
A_14_P114896
A_14_P114928
A_23_P329772
GE62753
GO:0000166
GO:0000278
GO:0000910
GO:0000916
GO:0000922
GO:0001778
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005643
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005774
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0006622
GO:0006886
GO:0006900
GO:0006914
GO:0006997
GO:0006998
GO:0007010
GO:0007032
GO:0007033
GO:0007049
GO:0007059
GO:0007080
GO:0007084
GO:0009838
GO:0010008
GO:0015031
GO:0016020
GO:0016192
GO:0016197
GO:0016236
GO:0016787
GO:0016887
GO:0019076
GO:0023052
GO:0030163
GO:0030496
GO:0031410
GO:0031468
GO:0031902
GO:0032367
GO:0032466
GO:0032880
GO:0034058
GO:0036258
GO:0039702
GO:0042060
GO:0043162
GO:0043226
GO:0044877
GO:0044878
GO:0046761
GO:0048471
GO:0048856
GO:0051301
GO:0061024
GO:0061640
GO:0061738
GO:0061764
GO:0061952
GO:0070062
GO:0071985
GO:0072319
GO:0072659
GO:0090148
GO:0090543
GO:0090611
GO:0097352
GO:0140014
GO:0140545
GO:0140657
GO:1903076
GO:1903543
GO:1903774
GO:1904896
GO:1904903
GO:1904949
HMNXSV003051082
ILMN_1708946
PH_hs_0026702
TC16000567.hg
g7019568_3p_at
Participates
as a component of
Vps/Vta1 [cytosol] (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
HCMV Vesicle Formation Complex [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
as an input of
HCMV Formation of Final Envelopment Complex (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
as an output of
HCMV Final Envelopment (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
Inferred To
Vps4 [cytosol]
(Drosophila melanogaster)
vps-4 [cytosol]
(Caenorhabditis elegans)
VPS4A [cytosol]
(Bos taurus)
VPS4A [cytosol]
(Canis familiaris)
VPS4A [cytosol]
(Dictyostelium discoideum)
VPS4A [cytosol]
(Gallus gallus)
VPS4A [cytosol]
(Mus musculus)
VPS4A [cytosol]
(Rattus norvegicus)
VPS4A [cytosol]
(Saccharomyces cerevisiae)
VPS4A [cytosol]
(Schizosaccharomyces pombe)
VPS4A [cytosol]
(Sus scrofa)
vps4a [cytosol]
(Danio rerio)
vps4a [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_037377.1
OpenTargets
ENSG00000132612
IntEnz
3.6.4.6
GeneCards
Q9UN37
HPA
ENSG00000132612-VPS4A
Ensembl
ENST00000254950
,
ENSP00000254950
,
ENSG00000132612
PRO
Q9UN37
Pharos - Targets
Q9UN37
PDB
2K3W
,
1YXR
,
2JQ9
HMDB Protein
HMDBP12005
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.788
9
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.659
8
UniProt:Q7LBR1 CHM1B
0.592
4
UniProt:Q9HD42-1 CHMP1A
0.558
2
UniProt:O95833 CLIC3
0.556
3
UniProt:O43633 CHMP2A
2
CHMP2A [cytosol]
(R-HSA-917734)
CHMP2A [endosome membrane]
(R-HSA-9631172)
0.547
4
UniProt:Q96K21 ANCHR
0.527
2
UniProt:O75351 VPS4B
1
VPS4B [cytosol]
(R-HSA-917719)
0.527
3
UniProt:Q9NP79 VTA1
1
VTA1 [cytosol]
(R-HSA-917735)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P53990 IST1
3
IST1 [extracellular region]
(R-HSA-6806231)
IST1 [azurophil granule lumen]
(R-HSA-6799169)
IST1 [cytosol]
(R-HSA-9668516)
0.527
2
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