Reactome | CHMP2A [cytosol]

CHMP2A [cytosol]

Stable Identifier

R-HSA-917734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Charged multivesicular body protein 2a, CHM2A_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O95630 STAMBP

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External Reference Information

External Reference

UniProt:O43633 CHMP2A

Gene Names

CHMP2A, BC2, CHMP2

Chain

chain:1-222

Reference Genes

BioGPS Gene:27243 CHMP2A

COSMIC (genes):CHMP2A CHMP2A

CTD Gene:27243 CHMP2A

dbSNP Gene:27243 CHMP2A

ENSEMBL:ENSG00000130724 CHMP2A

ENSEMBL_homo_sapiens_GENE:ENSG00000130724.10 CHMP2A

HGNC:30216 CHMP2A

KEGG Gene (Homo sapiens):27243 CHMP2A

Monarch:27243 CHMP2A

NCBI Gene:27243 CHMP2A

OMIM:610893 CHMP2A

UCSC:O43633 CHMP2A

Reference Transcript

Other Identifiers

11729602_a_at

16876182

202121_PM_s_at

202121_s_at

27243

3872984

3872985

3872987

3872989

3872991

3872993

3872995

3872996

3872997

3872998

39363_at

8039796

A_23_P153236

GE61840

GO:0000278

GO:0000421

GO:0000776

GO:0000785

GO:0000815

GO:0000910

GO:0001778

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005643

GO:0005694

GO:0005764

GO:0005765

GO:0005768

GO:0005771

GO:0005773

GO:0005828

GO:0005829

GO:0005856

GO:0005886

GO:0006914

GO:0006997

GO:0007010

GO:0007034

GO:0007040

GO:0007059

GO:0007080

GO:0008289

GO:0010324

GO:0010458

GO:0010824

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0019076

GO:0019904

GO:0030117

GO:0030163

GO:0030496

GO:0031210

GO:0031410

GO:0031468

GO:0031902

GO:0032509

GO:0032585

GO:0036258

GO:0039702

GO:0042060

GO:0043162

GO:0043226

GO:0045184

GO:0045324

GO:0046761

GO:0051258

GO:0051260

GO:0051469

GO:0061024

GO:0061763

GO:0061952

GO:0065003

GO:0070062

GO:0071985

GO:0090148

GO:0097352

GO:0140014

GO:1901673

GO:1902774

GO:1903543

GO:1903723

GO:1904903

GO:1904930

HMNXSV003029213

ILMN_1656621

ILMN_1671893

ILMN_1762932

PH_hs_0001138

TC19001922.hg

g7656921_3p_a_at

Participates

as a component of

AP1G2:HGS:CHMP2A [Golgi membrane] (Homo sapiens)

as an input of

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as a member of

CHMP2 [cytosol] (Homo sapiens)

Other forms of this molecule

CHMP2A [endosome membrane]

Inferred To

chmp2a2 [cytosol] (Dictyostelium discoideum)

chmp2a [cytosol] (Danio rerio)

chmp2a [cytosol] (Xenopus tropicalis)

Chmp2a [cytosol] (Mus musculus)

Chmp2a [cytosol] (Rattus norvegicus)

DID4 [cytosol] (Saccharomyces cerevisiae)

CHMP2A [cytosol] (Bos taurus)

CHMP2A [cytosol] (Canis familiaris)

CHMP2A [cytosol] (Gallus gallus)

CHMP2A [cytosol] (Sus scrofa)

Vps2 [cytosol] (Drosophila melanogaster)

did4 [cytosol] (Schizosaccharomyces pombe)

vps-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_055268.1, NP_940818.1

OpenTargets

ENSG00000130724

GeneCards

O43633

HPA

ENSG00000130724-CHMP2A

Ensembl

ENSG00000130724, ENSP00000471961, ENST00000597848, ENST00000601220, ENSP00000472680, ENSP00000469453, ENSP00000469240, ENST00000312547, ENST00000596708, ENST00000600118, ENSP00000310440

PRO

O43633

Pharos - Targets

O43633

PDB

7ZCG, 7ZCH

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WV92 MITD1			0.732	8
UniProt:Q9Y3E7 CHMP3	2	CHMP3 [cytosol] (R-HSA-917722) CHMP3 [endosome membrane] (R-HSA-9631191)	0.667	3
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.659	3
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.59	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q8NF50-2 DOCK8			0.556	3
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.547	4
UniProt:Q92882 OSTF1	3	OSTF1 [secretory granule lumen] (R-HSA-6803299) OSTF1 [extracellular region] (R-HSA-6806448) OSTF1 [ficolin-1-rich granule lumen] (R-HSA-6803301)	0.527	2
UniProt:Q9NZZ3 CHMP5	1	CHMP5 [cytosol] (R-HSA-917694)	0.527	2
UniProt:Q9UPQ4 TRIM35	1	TRIM35 [cytosol] (R-HSA-5624323)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:Q9NP79 VTA1	1	VTA1 [cytosol] (R-HSA-917735)	0.527	3
UniProt:Q9NPC8 SIX2	1	SIX2 [nucleoplasm] (R-HSA-9831037)	0.527	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.527	2
UniProt:Q16698 DECR1	1	DECR1 [mitochondrial matrix] (R-HSA-53523)	0.527	2
UniProt:Q9Y3E7-1 CHMP3			0.522	2

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