SLC46A1 transports FeHM from extracellular region to cytosol

Stable Identifier
R-HSA-917870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Extracellular ferriheme uptake through the apical membrane of enterocytes
Locations in the PathwayBrowser
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Uptake of iron from meat happens in the form of ferriheme, and via the same transporter that is used for folate. The process is more effective than taking up iron ions (Shayeghi M et al, 2005).

Literature References
PubMed ID Title Journal Year
16143108 Identification of an intestinal heme transporter

Shayeghi, M, Latunde-Dada, GO, Oakhill, JS, Laftah, AH, Takeuchi, K, Halliday, N, Khan, Y, Warley, A, McCann, FE, Hider, RC, Frazer, DM, Anderson, GJ, Vulpe, CD, Simpson, RJ, McKie, AT

Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
heme transporter activity of SLC46A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created