SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+

Stable Identifier
R-HSA-917933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Oxidation of Fe2+ by hephaestin
Locations in the PathwayBrowser
General
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Hephaestin oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+) after export from duodenal cells to enable its transport via transferrin (Griffiths et al, 2005).

Literature References
PubMed ID Title Journal Year
16274220 Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity

Griffiths, TA, Mauk, AG, MacGillivray, RT

Biochemistry 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ferroxidase activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created