Iron uptake and transport

Stable Identifier
R-HSA-917937
Type
Pathway
Species
Homo sapiens
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Summation

The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).

Literature References
PubMed ID Title Journal Year
20495089 Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Richardson, DR, Lane, DJ, Becker, EM, Huang, ML, Whitnall, M, Rahmanto, YS, Sheftel, AD, Ponka, P

Proc Natl Acad Sci U S A 2010
19381358 A general map of iron metabolism and tissue-specific subnetworks

Hower, V, Mendes, P, Torti, FM, Laubenbacher, R, Akman, S, Shulaev, V, Torti, SV

Mol Biosyst 2009
18259769 Lysosomes in iron metabolism, ageing and apoptosis

Kurz, T, Terman, A, Gustafsson, B, Brunk, UT

Histochem Cell Biol 2008
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Orthologous Events
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BioModels Database
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