Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TKFC [cytosol]
Stable Identifier
R-HSA-918185
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DAK, Dihydroxyacetone kinase (DAK), Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase, DHAK_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
ISGylated IFIH1 [cytosol] (Homo sapiens)
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
viral dsRNA binds IFIH1:TKFC (Homo sapiens)
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Fructose metabolism (Homo sapiens)
Fructose catabolism (Homo sapiens)
DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)
TKFC:2Mg2+ dimer [cytosol] (Homo sapiens)
TKFC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q3LXA3 TKFC
Gene Names
TKFC, DAK
Chain
chain:1-575
Reference Genes
BioGPS Gene:26007 TKFC
COSMIC (genes):TKFC TKFC
CTD Gene:26007 TKFC
dbSNP Gene:26007 TKFC
ENSEMBL:ENSG00000149476 TKFC
HGNC:24552 TKFC
KEGG:hsa:26007 TKFC
Monarch:26007 TKFC
NCBI Gene:26007 TKFC
OMIM:615844 TKFC
UCSC:Q3LXA3 TKFC
Reference Transcript
RefSeq:XM_017017523.1 TKFC
RefSeq:NM_015533.3 TKFC
RefSeq:XM_017017521.1 TKFC
Other Identifiers
11729596_a_at
11729597_x_at
11729598_at
11747294_a_at
16725556
218688_PM_at
218688_at
244627_PM_at
244627_at
26007
3332839
3332840
3332841
3332842
3332843
3332844
3332845
3332846
3332847
3332848
3332849
3332850
3332851
3332852
3332853
3332854
3332855
3332856
3332857
3332858
3332859
3332860
3332861
3332862
3332863
3332864
3332865
3332866
3332867
3332868
3332869
3332870
3332871
3332872
3332873
3332874
3332875
3332876
3332877
3332879
46570_at
71827_at
75777_at
7940451
A_14_P119405
A_14_P128749
A_14_P135628
A_23_P36129
A_33_P3245006
A_33_P3245011
GE85545
GO:0003824
GO:0004371
GO:0005515
GO:0005524
GO:0005634
GO:0005829
GO:0005975
GO:0006071
GO:0009975
GO:0016301
GO:0016740
GO:0016773
GO:0016829
GO:0019563
GO:0034012
GO:0039534
GO:0043226
GO:0045088
GO:0046835
GO:0046872
GO:0050354
GO:0061624
GO:0070062
GO:1901135
HMNXSV003029815
HMNXSV003032234
Hs.185794.0.A1_3p_at
ILMN_1678619
PH_hs_0000635
TC11000529.hg
TC11002698.hg
g13027381_3p_at
Participates
as an output of
SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)
IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
viral dsRNA binds IFIH1:TKFC (Homo sapiens)
as a component of
IFIH1:TKFC [cytosol] (Homo sapiens)
TKFC:2Mg2+ dimer [cytosol] (Homo sapiens)
Inferred To
TKFC [cytosol]
(Bos taurus)
TKFC [cytosol]
(Caenorhabditis elegans)
TKFC [cytosol]
(Canis familiaris)
TKFC [cytosol]
(Danio rerio)
TKFC [cytosol]
(Dictyostelium discoideum)
TKFC [cytosol]
(Gallus gallus)
TKFC [cytosol]
(Mus musculus)
TKFC [cytosol]
(Rattus norvegicus)
TKFC [cytosol]
(Saccharomyces cerevisiae)
TKFC [cytosol]
(Schizosaccharomyces pombe)
TKFC [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_056348.2
,
XP_016873010.1
,
XP_016873012.1
ENSEMBL
ENSP00000378360
,
ENST00000394900
OpenTargets
ENSG00000149476
IntEnz
2.7.1.29
HPA
ENSG00000149476-TKFC
PRO
Q3LXA3
Pharos - Targets
Q3LXA3
GlyGen
Q3LXA3
Orphanet
TKFC
HMDB Protein
HMDBP02553
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYX4 IFIH1
3
IFIH1 [cytosol]
(R-HSA-913536)
K48polyUb-IFIH1 [cytosol]
(R-HSA-3080557)
PolyUb-IFIH1 [cytosol]
(R-HSA-6782812)
0.616
5
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:P59665 DEFA1
9
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:Q96NR8 RDH12
6
RDH12 A126V [photoreceptor inner segment membrane]
(R-HSA-2471753)
RDH12 Q189* [photoreceptor inner segment membrane]
(R-HSA-2471667)
RDH12 Y226C [photoreceptor inner segment membrane]
(R-HSA-2471697)
RDH12 H151N [photoreceptor inner segment membrane]
(R-HSA-2471751)
RDH12 Ala269Glyfs*2 [photoreceptor inner segment membrane]
(R-HSA-2471748)
RDH12 [photoreceptor inner segment membrane]
(R-HSA-2464787)
0.527
2
UniProt:O75695 RP2
1
RP2 [cilium]
(R-HSA-5624052)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text