K63polyUb-DDX58 [cytosol]

Stable Identifier
R-HSA-918191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I
Icon
K63polyUb-DDX58 [cytosol] icon
K63polyUb-DDX58 [cytosol] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Takeuchi, O, Gack, MU, Joo, CH, Inoue, S, Akira, S, Shin, YC, Liang, C, Jung, JU, Sun, L, Urano, T, Chen, Z

Nature 2007
15208624 The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Taira, K, Shinobu, N, Yoneyama, M, Fujita, T, Miyagishi, M, Kikuchi, M, Imaizumi, T, Natsukawa, T

Nat Immunol 2004
19484123 REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

Chen, DY, Gao, D, Yang, YK, Jiang, ZF, Diao, FC, Zhou, X, Zhai, ZH, Wang, RP, Li, MD

PLoS One 2009
External Reference Information
External Reference
UniProt:O95786 DDX58
Gene Names
DDX58
Chain
chain:1-925
Reference Genes
BioGPS Gene:23586 DDX58
COSMIC (genes):DDX58 DDX58
CTD Gene:23586 DDX58
dbSNP Gene:23586 DDX58
ENSEMBL:ENSG00000107201.11 DDX58
HGNC:19102 DDX58
KEGG Gene (Homo sapiens):23586 DDX58
Monarch:23586 DDX58
NCBI Gene:23586 DDX58
OMIM:609631 DDX58
UCSC:O95786 DDX58
Reference Transcript
Other Identifiers
0005220180
11733149_a_at
11755819_a_at
11756330_a_at
17093090
218943_PM_s_at
218943_s_at
222793_PM_at
222793_at
23586
242961_3p_x_at
242961_PM_x_at
242961_x_at
3203087
3203088
3203089
3203090
3203091
3203092
3203093
3203095
3203096
3203097
3203098
3203101
3203103
3203104
3203105
3203106
3203107
3203108
3203109
3203110
3203111
3203113
3203115
3203121
59215_at
76098_r_at
77749_at
8160559
A_23_P20814
A_33_P3372910
A_33_P3418170
GE54334
GO:0000166
GO:0002230
GO:0002376
GO:0002735
GO:0003674
GO:0003676
GO:0003677
GO:0003690
GO:0003723
GO:0003724
GO:0003725
GO:0003727
GO:0004386
GO:0005515
GO:0005524
GO:0005525
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0006351
GO:0006355
GO:0008150
GO:0008270
GO:0009597
GO:0009615
GO:0010467
GO:0010628
GO:0015629
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0023052
GO:0030054
GO:0030334
GO:0031625
GO:0032587
GO:0032725
GO:0032727
GO:0032728
GO:0032755
GO:0032757
GO:0032760
GO:0032991
GO:0034344
GO:0039528
GO:0039529
GO:0042802
GO:0042995
GO:0043167
GO:0043226
GO:0043330
GO:0045087
GO:0045944
GO:0046872
GO:0048870
GO:0051091
GO:0051607
GO:0060760
GO:0071360
GO:0098542
GO:0140374
GO:0140657
GO:1990904
HMNXSV003031097
Hs.145612.0.S2_3p_at
Hs.263536.0.A1_3p_at
Hs.263536.0.A1_3p_x_at
ILMN_1797001
PH_hs_0005775
PH_hs_0025667
TC09000999.hg
g7657515_3p_a_at
Participates
as an input of
as a component of
Other forms of this molecule
PolyUb-DDX58 [cytosol]
K48polyUb-DDX58 [cytosol]
DDX58 [cytosol]
Inferred To
drh-3 [cytosol] (Caenorhabditis elegans)
helF [cytosol] (Dictyostelium discoideum)
K63polyUb-DDX58 [cytosol] (Bos taurus)
K63polyUb-DDX58 [cytosol] (Canis familiaris)
K63polyUb-DDX58 [cytosol] (Mus musculus)
K63polyUb-DDX58 [cytosol] (Sus scrofa)
ddx58 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154
Coordinate
154
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164
Coordinate
164
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172
Coordinate
172
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
IntEnz
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
HMDB Protein
PDB
Interactors (23)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q7Z434 MAVS  2 0.956 19
 UniProt:Q14258 TRIM25  2 0.845 11
 UniProt:P0DTC9 N  13 0.786 15
 UniProt:P0DTD1-PRO_0000449623 REP      0.72 6
 UniProt:O75569 PRKRA  1 0.688 5
 ChEBI:84491 POLY(I      0.656 3
 UniProt:O95786 DDX58  4 0.656 3
 IntAct:EBI-26608251 NC      0.65 9
 UniProt:F1BA49 F1BA49      0.59 5
 UniProt:P59596 M  10 0.589 4
 UniProt:Q7Z2W4-2 ZC3HAV1      0.589 4
 IntAct:EBI-26977473 3PRNA      0.558 2
 UniProt:Q920D5 CASPC      0.557 4
 IntAct:EBI-26977583 3’UTR-SENSE      0.544 4
 UniProt:Q6IUF9 Z      0.544 3
 UniProt:Q6UY71 Z      0.544 3
 UniProt:Q6IVU5 Z      0.544 3
 UniProt:Q9NQC7 CYLD  2 0.524 2
 UniProt:P04487 RNB      0.524 4
 UniProt:Q7Z2W4 ZC3HAV1  2 0.524 3
 UniProt:Q96S55 WRIP1      0.499 2
 UniProt:P0DTC5 M  10 0.463 3
 UniProt:P0DTD2 9b  3 0.463 2
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