K63polyUb-DDX58 [cytosol]

Stable Identifier
R-HSA-918191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I
Icon
K63polyUb-DDX58 [cytosol] icon
K63polyUb-DDX58 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
15208624 The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M, Kikuchi, M, Natsukawa, T, Shinobu, N, Imaizumi, T, Miyagishi, M, Taira, K, Fujita, T

Nat Immunol 2004
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Gack, MU, Shin, YC, Joo, CH, Urano, T, Liang, C, Sun, L, Takeuchi, O, Akira, S, Chen, Z, Inoue, S, Jung, JU

Nature 2007
19484123 REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

Gao, D, Yang, YK, Wang, RP, Zhou, X, Diao, FC, Li, MD, Zhai, ZH, Jiang, ZF, Chen, DY

PLoS One 2009
External Reference Information
External Reference
UniProt:O95786 DDX58
Gene Names
DDX58
Chain
chain:1-925
Reference Genes
BioGPS Gene:23586 DDX58
COSMIC (genes):DDX58 DDX58
CTD Gene:23586 DDX58
dbSNP Gene:23586 DDX58
ENSEMBL:ENSG00000107201 DDX58
HGNC:19102 DDX58
KEGG Gene (Homo sapiens):23586 DDX58
Monarch:23586 DDX58
NCBI Gene:23586 DDX58
OMIM:609631 DDX58
UCSC:O95786 DDX58
Reference Transcript
Other Identifiers
0005220180
11733149_a_at
11755819_a_at
11756330_a_at
12643
17093090
218943_s_at
222793_at
23586
242961_3p_x_at
242961_x_at
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3203087
3203088
3203089
3203090
3203091
3203092
3203093
3203095
3203096
3203097
3203098
3203101
3203103
3203104
3203105
3203106
3203107
3203108
3203109
3203110
3203111
3203113
3203115
3203121
3LRN
3LRR
3NCU
3OG8
3ZD6
3ZD7
47193
4AY2
4BPB
4NQK
4ON9
4P4H
59215_at
5E3H
5F98
5F9F
5F9H
6GPG
76098_r_at
77749_at
8160559
A2A376
A_23_P20814
A_33_P3372910
A_33_P3418170
AAD19826
AAI32787
AAI36611
AF038963
AL137608
AL161783
AL353671
BC132786
BC136610
BX647917
CAB012643
CAB70840
CAI46068
CCDS6526
CH471071
DDX58
DDX58-202
EAW58548
ENSG00000107201
ENSP00000369213
ENST00000379883
ENST00000379883.2
EntrezGene:23586
EntrezGene:DDX58
g7657515_3p_a_at
GE54334
GO:0000166
GO:0002230
GO:0002376
GO:0002735
GO:0003674
GO:0003676
GO:0003677
GO:0003690
GO:0003723
GO:0003725
GO:0003727
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0006464
GO:0006810
GO:0006950
GO:0007165
GO:0008150
GO:0008270
GO:0009058
GO:0009597
GO:0009615
GO:0010628
GO:0015629
GO:0016020
GO:0016032
GO:0016579
GO:0016787
GO:0019899
GO:0030054
GO:0030334
GO:0031625
GO:0032480
GO:0032587
GO:0032725
GO:0032727
GO:0032728
GO:0032755
GO:0032757
GO:0034344
GO:0034641
GO:0035549
GO:0039528
GO:0039529
GO:0040011
GO:0042802
GO:0042995
GO:0043167
GO:0043226
GO:0043330
GO:0044403
GO:0045087
GO:0045944
GO:0046872
GO:0048870
GO:0051091
GO:0051607
GO:0060760
GO:0071360
GO:1902741
GO:1904469
GO:2000778
HGNC:19102
HPA047193
Hs.145612.0.S2_3p_at
Hs.263536.0.A1_3p_at
Hs.263536.0.A1_3p_x_at
ILMN_1797001
IPR001650
IPR011545
IPR014001
IPR021673
IPR027417
IPR031964
IPR038557
IPR041204
MIM:609631
MIM:616298
NM_014314
NP_055129
PF00270
PF00271
PF11648
PF16739
PF18119
PH_hs_0005775
PH_hs_0025667
SM00487
SM00490
TC09000999.hg
UPI000013C841
Participant Of
input
hasComponent
Other forms of this molecule
PolyUb-DDX58 [cytosol]
PolyUb-DDX58 [cytosol]
K48polyUb-DDX58 [cytosol]
DDX58 [cytosol]
Inferred To
Homologues of K63polyUb-DDX58 [cytosol] (Caenorhabditis elegans)
Homologues of K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)
K63polyUb-DDX58 [cytosol] (Bos taurus)
K63polyUb-DDX58 [cytosol] (Caenorhabditis elegans)
K63polyUb-DDX58 [cytosol] (Canis familiaris)
K63polyUb-DDX58 [cytosol] (Dictyostelium discoideum)
K63polyUb-DDX58 [cytosol] (Mus musculus)
K63polyUb-DDX58 [cytosol] (Plasmodium falciparum)
K63polyUb-DDX58 [cytosol] (Rattus norvegicus)
K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)
K63polyUb-DDX58 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154
Coordinate
154
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164
Coordinate
164
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172
Coordinate
172
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
OpenTargets
IntEnz
GeneCards
PRO
Orphanet
HMDB Protein
PDB
Interactors (14)