K63polyUb-DDX58 [cytosol]

Stable Identifier
R-HSA-918191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I
Icon
K63polyUb-DDX58 [cytosol] icon
K63polyUb-DDX58 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Takeuchi, O, Gack, MU, Joo, CH, Inoue, S, Akira, S, Shin, YC, Liang, C, Jung, JU, Sun, L, Urano, T, Chen, Z

Nature 2007
15208624 The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Taira, K, Shinobu, N, Yoneyama, M, Fujita, T, Miyagishi, M, Kikuchi, M, Imaizumi, T, Natsukawa, T

Nat Immunol 2004
19484123 REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

Chen, DY, Gao, D, Yang, YK, Jiang, ZF, Diao, FC, Zhou, X, Zhai, ZH, Wang, RP, Li, MD

PLoS One 2009
External Reference Information
External Reference
UniProt:O95786 RIGI
Gene Names
RIGI, DDX58
Chain
chain:1-925
Reference Genes
BioGPS Gene:23586 RIGI
COSMIC (genes):DDX58 RIGI
CTD Gene:23586 RIGI
dbSNP Gene:23586 RIGI
ENSEMBL:ENSG00000107201 DDX58
HGNC:19102 RIGI
KEGG:hsa:23586 RIGI
Monarch:23586 RIGI
NCBI Gene:23586 RIGI
OMIM:609631 RIGI
UCSC:O95786 RIGI
Reference Transcript
Participates
as an input of
as a component of
Other forms of this molecule
DDX58 [cytosol]
K48polyUb-DDX58 [cytosol]
PolyUb-DDX58 [cytosol]
Inferred To
Homologues of K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)
helF [cytosol] (Dictyostelium discoideum)
rigi [cytosol] (Xenopus tropicalis)
K63polyUb-DDX58 [cytosol] (Bos taurus)
K63polyUb-DDX58 [cytosol] (Caenorhabditis elegans)
K63polyUb-DDX58 [cytosol] (Mus musculus)
K63polyUb-DDX58 [cytosol] (Plasmodium falciparum)
K63polyUb-DDX58 [cytosol] (Rattus norvegicus)
K63polyUb-DDX58 [cytosol] (Saccharomyces cerevisiae)
K63polyUb-DDX58 [cytosol] (Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154
Coordinate
154
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164
Coordinate
164
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172
Coordinate
172
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
Guide to Pharmacology - Targets
ENSEMBL
OpenTargets
GeneCards
HPA
PRO
Pharos - Targets
Orphanet
GlyGen
HMDB Protein
PDB
Interactors (25)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q7Z434 MAVS  2 0.956 19
 UniProt:Q14258 TRIM25  2 0.845 9
 UniProt:P0DTC9 N  13 0.786 15
 UniProt:P0DTD1-PRO_0000449623 REP      0.72 6
 UniProt:O75569 PRKRA  2 0.688 5
 UniProt:O95786 RIGI  4 0.656 3
 ChEBI:84491 POLY(I      0.656 3
 IntAct:EBI-26608251 NC      0.65 9
 UniProt:Q8TAT6 NPLOC4  2 0.619 6
 UniProt:Q96EQ8 RNF125  2 0.591 4
 UniProt:A0A0B5AC19 NSS      0.59 5
 UniProt:P59596 M  10 0.589 4
 UniProt:Q7Z2W4-2 ZC3HAV1      0.589 4
 IntAct:EBI-26977473 3PRNA      0.558 2
 UniProt:Q920D5 CASPC      0.557 4
 UniProt:Q6UY71 Z      0.544 3
 IntAct:EBI-26977583 3’UTR-SENSE      0.544 4
 UniProt:Q6IVU5 Z      0.544 3
 UniProt:Q6IUF9 Z      0.544 3
 UniProt:Q9NQC7 CYLD  3 0.524 2
 UniProt:P04487 RNB      0.524 4
 UniProt:Q7Z2W4 ZC3HAV1  2 0.524 3
 UniProt:Q96S55 WRIP1      0.499 2
 UniProt:P0DTC5 M  10 0.463 3
 UniProt:P0DTD2 9b  3 0.463 2
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