K63polyUb-DDX58 [cytosol]

Stable Identifier
R-HSA-918191
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63polyUb-RIG-I, K63 polyuniquitinated RIG-I, Ub-RIG-I
Icon
K63polyUb-DDX58 [cytosol] icon
K63polyUb-DDX58 [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
15208624 The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Yoneyama, M, Kikuchi, M, Natsukawa, T, Shinobu, N, Imaizumi, T, Miyagishi, M, Taira, K, Fujita, T

Nat Immunol 2004
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Gack, MU, Shin, YC, Joo, CH, Urano, T, Liang, C, Sun, L, Takeuchi, O, Akira, S, Chen, Z, Inoue, S, Jung, JU

Nature 2007
19484123 REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

Gao, D, Yang, YK, Wang, RP, Zhou, X, Diao, FC, Li, MD, Zhai, ZH, Jiang, ZF, Chen, DY

PLoS One 2009
External Reference Information
External Reference
UniProt:O95786 DDX58
Gene Names
DDX58
Chain
chain:1-925
Reference Genes
BioGPS Gene:23586 DDX58
COSMIC (genes):DDX58 DDX58
CTD Gene:23586 DDX58
dbSNP Gene:23586 DDX58
ENSEMBL:ENSG00000107201 DDX58
HGNC:19102 DDX58
KEGG Gene (Homo sapiens):23586 DDX58
Monarch:23586 DDX58
NCBI Gene:23586 DDX58
OMIM:609631 DDX58
UCSC:O95786 DDX58
Reference Transcript
Other Identifiers
0005220180
11733149_a_at
11755819_a_at
11756330_a_at
17093090
218943_s_at
222793_at
23586
242961_3p_x_at
242961_x_at
3203087
3203088
3203089
3203090
3203091
3203092
3203093
3203095
3203096
3203097
3203098
3203101
3203103
3203104
3203105
3203106
3203107
3203108
3203109
3203110
3203111
3203113
3203115
3203121
59215_at
76098_r_at
77749_at
8160559
A_23_P20814
A_33_P3372910
A_33_P3418170
GE54334
GO:0000166
GO:0002230
GO:0002376
GO:0002735
GO:0003674
GO:0003676
GO:0003677
GO:0003690
GO:0003723
GO:0003724
GO:0003725
GO:0003727
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0006464
GO:0006810
GO:0006950
GO:0007165
GO:0007267
GO:0008150
GO:0008270
GO:0009058
GO:0009597
GO:0009615
GO:0010628
GO:0015031
GO:0015629
GO:0016020
GO:0016032
GO:0016579
GO:0016787
GO:0016887
GO:0019899
GO:0030054
GO:0030334
GO:0031625
GO:0032480
GO:0032587
GO:0032725
GO:0032727
GO:0032728
GO:0032755
GO:0032757
GO:0032991
GO:0034344
GO:0034641
GO:0039528
GO:0039529
GO:0040011
GO:0042802
GO:0042995
GO:0043167
GO:0043226
GO:0043330
GO:0044403
GO:0045087
GO:0045944
GO:0046872
GO:0048870
GO:0051091
GO:0051607
GO:0060760
GO:0071360
GO:0140374
GO:1904469
GO:1990904
Hs.145612.0.S2_3p_at
Hs.263536.0.A1_3p_at
Hs.263536.0.A1_3p_x_at
ILMN_1797001
PH_hs_0005775
PH_hs_0025667
TC09000999.hg
g7657515_3p_a_at
Participant Of
input
hasComponent
Other forms of this molecule
PolyUb-DDX58 [cytosol]
PolyUb-DDX58 [cytosol]
K48polyUb-DDX58 [cytosol]
DDX58 [cytosol]
Inferred To
drh-3 [cytosol] (Caenorhabditis elegans)
DDX58 [cytosol] (Canis familiaris)
helF [cytosol] (Dictyostelium discoideum)
Ddx58 [cytosol] (Mus musculus)
K63polyUb-DDX58 [cytosol] (Bos taurus)
K63polyUb-DDX58 [cytosol] (Plasmodium falciparum)
ddx58 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 154
Coordinate
154
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 164
Coordinate
164
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 172
Coordinate
172
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
OpenTargets
IntEnz
GeneCards
HPA
Ensembl
PRO
Orphanet
HMDB Protein
PDB
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q7Z434 MAVS  2 0.926 13
 UniProt:O75569 PRKRA  1 0.688 5
 UniProt:Q7Z2W4-2 ZC3HAV1      0.61 4
 UniProt:F1BA49 F1BA49      0.59 5
 UniProt:P59596 M  8 0.589 4
 UniProt:Q920D5 CASPC      0.557 4
 UniProt:Q14258 TRIM25  2 0.547 4
 UniProt:Q6IUF9 Z      0.544 3
 UniProt:Q6UY71 Z      0.544 3
 UniProt:Q6IVU5 Z      0.544 3
 UniProt:O95786 DDX58  5 0.524 2
 UniProt:Q9NQC7 CYLD  2 0.524 2
 UniProt:P04487 RNB      0.524 4
 UniProt:Q7Z2W4 ZC3HAV1  2 0.524 3
 UniProt:Q96S55 WRIP1      0.499 2
 UniProt:P0DTD2 9b  1 0.463 2
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