Reactome | Recruitment of TRAF3 to MAVS

Recruitment of TRAF3 to MAVS

Stable Identifier

R-HSA-918227

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating MAVS-dependent type I IFN production. TRAF3 interacts directly with MAVS (IPS-1) through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) within MAVS (IPS-1).

Literature References

PubMed ID	Title	Journal	Year
16306936	Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Perry, A, Saha, SK, Oganesyan, G, He, JQ, Guo, B, Shahangian, A, Cheng, G, Zarnegar, B	Nature	2006
17190786	Antiviral signaling through pattern recognition receptors Kawai, T, Akira, S	J Biochem	2007
16858409	Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif Pietras, EM, Saha, SK, Oganesyan, G, He, JQ, Wang, Y, Shahangian, A, Kang, JR, Cheng, G, Zarnegar, B, Liu, SY, Shiba, TL	EMBO J	2006