Reactome | Recruitment of TRAF3 to MAVS

Recruitment of TRAF3 to MAVS

Stable Identifier

R-HSA-918227

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating MAVS-dependent type I IFN production. TRAF3 interacts directly with MAVS (IPS-1) through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) within MAVS (IPS-1).

Literature References

PubMed ID	Title	Journal	Year
16306936	Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G	Nature	2006
17190786	Antiviral signaling through pattern recognition receptors Kawai, T, Akira, S	J Biochem	2007
16858409	Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif Saha, SK, Pietras, EM, He, JQ, Kang, JR, Liu, SY, Oganesyan, G, Shahangian, A, Zarnegar, B, Shiba, TL, Wang, Y, Cheng, G	EMBO J	2006