Recruitment of TRAF3 to MAVS

Stable Identifier
R-HSA-918227
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
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TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating IPS-1 dependent type I IFN production. TRAF3 interacts directly with IPS-1 through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) with in IPS-1.

Literature References
PubMed ID Title Journal Year
17190786 Antiviral signaling through pattern recognition receptors

Kawai, T, Akira, S

J Biochem 2007
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G

Nature 2006
16858409 Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Saha, SK, Pietras, EM, He, JQ, Kang, JR, Liu, SY, Oganesyan, G, Shahangian, A, Zarnegar, B, Shiba, TL, Wang, Y, Cheng, G

EMBO J 2006
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