TRAF3-dependent IRF activation pathway

Stable Identifier
R-HSA-918233
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAVS via its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.

Literature References
PubMed ID Title Journal Year
17190786 Antiviral signaling through pattern recognition receptors

Kawai, T, Akira, S

J Biochem 2007
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G

Nature 2006
Participants
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