Reactome: A Curated Pathway Database

TRAF3-dependent IRF activation pathway

Stable Identifier
R-HSA-918233
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAVS via its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.

Literature References
Participants
Participant Of
Orthologous Events