Reactome: A Curated Pathway Database

RGS proteins that are GAPs for G alpha (q)

Stable Identifier
R-HSA-921130
Type
PositiveRegulation
Locations in the PathwayBrowser
Summation

Regulators of G protein signaling (RGS) proteins all contain a 120 amino acid RGS domain that defines the family and enable the protein to bind to active G alpha:GTP. RGS binding greatly increases the intrinsic GTPase activity of G alpha subunits; RGS proteins are GTPase-activating proteins (GAPs) for G alpha. In vitro there is often little or no selectivity for GPCR or G alpha subtype, but in vitro there are marked preferences. Some RGS proteins contain many additional domains and have diverse functions, not limited to modulating GPCR signaling (McCoy & Hepler 2009).

Literature References
Regulation participants
Regulation type
PositiveRegulation