p-STAT5 dissociates from the receptor complex

Stable Identifier
R-HSA-921155
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).

Literature References
PubMed ID Title Journal Year
9030599 A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation

Behrmann, I, Janzen, C, Gerhartz, C, Schmitz-Van de Leur, H, Hermanns, H, Heesel, B, Graeve, L, Horn, F, Tavernier, J, Heinrich, PC

J Biol Chem 1997
Participants
Participant Of
Orthologous Events
Authored
Reviewed