Reactome | UPF1 [cytosol]

UPF1 [cytosol]

Stable Identifier

R-HSA-927734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Regulator of nonsense transcripts 1, RENT1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O95758 PTBP3

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External Reference Information

External Reference

UniProt:Q92900 UPF1

Gene Names

UPF1, KIAA0221, RENT1

Chain

chain:1-1129

Reference Genes

BioGPS Gene:5976 UPF1

COSMIC (genes):UPF1 UPF1

CTD Gene:5976 UPF1

dbSNP Gene:5976 UPF1

ENSEMBL:ENSG00000005007 UPF1

HGNC:9962 UPF1

KEGG:hsa:5976 UPF1

Monarch:5976 UPF1

NCBI Gene:5976 UPF1

OMIM:601430 UPF1

UCSC:Q92900 UPF1

Reference Transcript

Participates

as an output of

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

p-4S-UPF1 [cytosol]

Inferred To

NAM7 [cytosol] (Saccharomyces cerevisiae)

smg-2 [cytosol] (Caenorhabditis elegans)

UPF1 [cytosol] (Bos taurus)

UPF1 [cytosol] (Canis familiaris)

UPF1 [cytosol] (Gallus gallus)

UPF1 [cytosol] (Plasmodium falciparum)

UPF1 [cytosol] (Sus scrofa)

upf1 [cytosol] (Danio rerio)

upf1 [cytosol] (Dictyostelium discoideum)

upf1 [cytosol] (Schizosaccharomyces pombe)

upf1 [cytosol] (Xenopus tropicalis)

Upf1 [cytosol] (Drosophila melanogaster)

Upf1 [cytosol] (Mus musculus)

Upf1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001284478.1, NP_002902.2

OpenTargets

ENSG00000005007

ENSEMBL

ENSP00000470142, ENSG00000005007, ENSP00000262803, ENST00000262803, ENST00000599848

GeneCards

UPF1

HPA

ENSG00000005007-UPF1

PRO

Q92900

Pharos - Targets

Q92900

GlyGen

Q92900

PDB

6Z3R, 2GK7, 2GK6, 2GJK, 2WJV, 2WJY, 2XZO, 8RXB, 6EJ5, 2XZP, 2IYK

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.956	30
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.886	11
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.783	13
UniProt:O95793 STAU1			0.777	6
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.766	6
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.758	7
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.725	5
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.69	9
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.677	4
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.643	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:Q8IU60 DCP2	1	DCP2 [cytosol] (R-HSA-429937)	0.641	3
UniProt:Q9NZB2 F120A			0.623	3
UniProt:Q92540 SMG7	1	SMG7 [cytosol] (R-HSA-927838)	0.623	4
UniProt:Q9NPJ4 PNRC2	1	PNRC2 [cytosol] (R-HSA-8879146)	0.616	9
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.595	3
UniProt:Q9UN81 LORF1			0.576	6
UniProt:P15170 GSPT1	1	GSPT1 [cytosol] (R-HSA-8865759)	0.564	3
UniProt:Q7Z422 SZRD1			0.564	2
UniProt:Q9H1J1 UPF3A	1	UPF3A [cytosol] (R-HSA-927801)	0.564	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [extracellular region] (R-HSA-9017791) YBX1 [nucleoplasm] (R-HSA-72041)	0.527	2
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.527	2
UniProt:O95758 PTBP3			0.527	4
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.527	3
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	3
UniProt:Q12905 ILF2	5	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [cytosol] (R-HSA-9836392)	0.527	4
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.524	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.524	3
UniProt:P55265 ADAR	2	ADAR [nucleoplasm] (R-HSA-53939) ADAR1 [cytosol] (R-HSA-9835955)	0.524	3
UniProt:Q14493 SLBP	2	SLBP [nucleoplasm] (R-HSA-64547) SLBP [cytosol] (R-HSA-141613)	0.499	3
UniProt:Q9BZI7-2 UPF3B			0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:Q6ZN17 LN28B			0.483	2
UniProt:Q12906 ILF3	3	ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [nucleoplasm] (R-HSA-9760401)	0.483	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.462	3