Reactome | UPF2 [cytosol]

UPF2 [cytosol]

Stable Identifier

R-HSA-927799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Regulator of nonsense transcripts 2, RENT2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HAU5 UPF2

Gene Names

UPF2, KIAA1408, RENT2

Chain

chain:1-1272

Reference Genes

BioGPS Gene:26019 UPF2

COSMIC (genes):UPF2 UPF2

CTD Gene:26019 UPF2

dbSNP Gene:26019 UPF2

ENSEMBL:ENSG00000151461 UPF2

ENSEMBL_homo_sapiens_GENE:ENSG00000151461.20 UPF2

HGNC:17854 UPF2

KEGG Gene (Homo sapiens):26019 UPF2

Monarch:26019 UPF2

NCBI Gene:26019 UPF2

OMIM:605529 UPF2

UCSC:Q9HAU5 UPF2

Reference Transcript

Other Identifiers

11745895_a_at

11745896_a_at

11755113_a_at

16711761

203519_PM_s_at

203519_s_at

26019

3277671

3277672

3277673

3277674

3277679

3277680

3277682

3277684

3277685

3277687

3277691

3277692

3277694

3277695

3277696

3277697

3277698

3277699

3277700

3277704

3277708

3277709

3277710

3277711

3277712

3277721

3277722

3277723

3277725

3277726

3277727

3277728

3277729

3277730

3277735

3277736

35722_at

59168_at

64296_at

7932041

A_23_P149818

A_33_P3218760

A_33_P3218768

A_33_P3218772

A_33_P3279049

GE53955

GO:0000184

GO:0001889

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005844

GO:0006406

GO:0006913

GO:0016071

GO:0031100

GO:0035145

GO:0036464

GO:0042162

GO:0043226

GO:0048471

GO:0048856

HMNXSV003034402

ILMN_1679417

ILMN_1739283

ILMN_1796305

ILMN_2383693

PH_hs_0000436

TC10001039.hg

TC10002474.hg

g11693131_3p_a_at

p33748

Participates

as a component of

Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)

Inferred To

UPF2 [cytosol] (Bos taurus)

UPF2 [cytosol] (Canis familiaris)

UPF2 [cytosol] (Dictyostelium discoideum)

UPF2 [cytosol] (Gallus gallus)

UPF2 [cytosol] (Plasmodium falciparum)

UPF2 [cytosol] (Sus scrofa)

smg-3 [cytosol] (Caenorhabditis elegans)

NMD2 [cytosol] (Saccharomyces cerevisiae)

Upf2 [cytosol] (Drosophila melanogaster)

Upf2 [cytosol] (Mus musculus)

Upf2 [cytosol] (Rattus norvegicus)

Ghost homologue of UPF2 [cytosol] (Danio rerio)

upf2 [cytosol] (Schizosaccharomyces pombe)

upf2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_542166.1, NP_056357.1

OpenTargets

ENSG00000151461

HPA

ENSG00000151461-UPF2

GeneCards

Q9HAU5

Ensembl

ENSP00000350221, ENSP00000348708, ENST00000397053, ENST00000357604, ENSP00000380244, ENST00000356352, ENSG00000151461

PRO

Q9HAU5

Pharos - Targets

Q9HAU5

PDB

1UW4, 4CEK, 7NWU, 2WJV, 4CEM, 7QG6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.953	29
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.897	9
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.704	7