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SMG7 [cytosol]
Stable Identifier
R-HSA-927838
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein SMG7, SMG7_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92540 SMG7
Gene Names
SMG7, C1orf16, EST1C, KIAA0250
Chain
initiator methionine:1, chain:2-1137
Reference Genes
BioGPS Gene:9887 SMG7
COSMIC (genes):SMG7 SMG7
CTD Gene:9887 SMG7
dbSNP Gene:9887 SMG7
ENSEMBL:ENSG00000116698 SMG7
HGNC:16792 SMG7
KEGG Gene (Homo sapiens):9887 SMG7
Monarch:9887 SMG7
NCBI Gene:9887 SMG7
OMIM:610964 SMG7
UCSC:Q92540 SMG7
Reference Transcript
RefSeq:NM_201569.2 SMG7
RefSeq:NM_173156.2 SMG7
RefSeq:NM_001174061.1 SMG7
RefSeq:NM_201568.2 SMG7
Other Identifiers
0006400315
0006770195
11718521_a_at
11718522_a_at
11755243_a_at
16674880
201793_x_at
201794_s_at
217189_s_at
2371256
2371257
2371258
2371267
2371270
2371271
2371274
2371276
2371277
2371278
2371279
2371282
2371283
2371285
2371288
2371290
2371291
2371292
2371293
2371294
2371295
2371296
2371298
2371299
2371302
2371303
2371305
2371306
2371309
2371310
2371311
2371312
2371313
2371314
2371315
2371316
39770_at
7908097
9887
A_14_P102200
A_14_P119364
A_23_P201647
D87437_at
GE57394
GO:0000184
GO:0003674
GO:0003677
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005697
GO:0005737
GO:0005829
GO:0005856
GO:0006259
GO:0006406
GO:0006810
GO:0006913
GO:0007004
GO:0008150
GO:0009056
GO:0009058
GO:0015031
GO:0019899
GO:0032210
GO:0032991
GO:0034641
GO:0034655
GO:0035303
GO:0042162
GO:0042592
GO:0043226
GO:0045111
GO:0051276
GO:0051721
GO:0070034
Hs.15087.0.A1_3p_a_at
Hs.15087.1.A1_3p_a_at
ILMN_1690469
ILMN_1706553
ILMN_2368597
PH_hs_0022121
TC01001586.hg
g7662023_3p_a_at
Participant Of
output
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
input
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
hasComponent
mRNA Cleaved by SMG6 [cytosol]
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
Inferred To
smg7 [cytosol] (Danio rerio)
Ghost homologue of SMG7 [cytosol] (Caenorhabditis elegans)
Ghost homologue of SMG7 [cytosol] (Dictyostelium discoideum)
Ghost homologue of SMG7 [cytosol] (Drosophila melanogaster)
Ghost homologue of SMG7 [cytosol] (Plasmodium falciparum)
Homologues of SMG7 [cytosol] (Saccharomyces cerevisiae)
SMG7 [cytosol] (Bos taurus)
SMG7 [cytosol] (Canis familiaris)
SMG7 [cytosol] (Gallus gallus)
SMG7 [cytosol] (Schizosaccharomyces pombe)
SMG7 [cytosol] (Sus scrofa)
SMG7 [cytosol] (Xenopus tropicalis)
Smg7 [cytosol] (Mus musculus)
Smg7 [cytosol] (Rattus norvegicus)
ESL2 [cytosol] (Saccharomyces cerevisiae)
EST1 [cytosol] (Saccharomyces cerevisiae)
EBS1 [cytosol] (Saccharomyces cerevisiae)
ESL1 [cytosol] (Saccharomyces cerevisiae)
Cross References
RefSeq
NP_775179.1
,
NP_963862.1
,
NP_963863.2
,
NP_001167532.1
OpenTargets
ENSG00000116698
GeneCards
Q92540
HPA
ENSG00000116698-SMG7
Ensembl
ENSP00000340766
,
ENSP00000421358
,
ENST00000515829
,
ENSG00000116698
,
ENST00000507469
,
ENST00000508461
,
ENST00000347615
,
ENSP00000425133
,
ENSP00000426915
PRO
Q92540
PDB
1YA0
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92900-2 UPF1
0.527
2
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.499
3
UniProt:Q9UPR3 SMG5
1
SMG5 [cytosol]
(R-HSA-927867)
0.499
5
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.462
2
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