About
About Reactome
News
Reactome Team
Scientific Advisory Board
Other Reactomes
License Agreement
Reactome Disclaimer
Content
Table of Contents
DOIs
Data Schema
Editorial Calendar
Statistics
ORCID Integration Project
Documentation
User Guide
Developer Guide
Data Model
Computational inferred events
Object/Relational Mapping
Wiki
Linking to Reactome
Referencing Reactome
Tools
Pathway Browser
Analyze Data
Species Comparison
ReactomeFIViz
Advanced Search
Author/Reviewer Search
Analysis Service
Content Service
Community
Reactome Outreach
Reactome Events
Reactome Icon Library
Reactome Publications
Reactome Training
Partners
Papers Citing Reactome
Mailing List
Download
Contact
mRNA Cleaved by SMG6
Stable Identifier
R-HSA-927845
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20930030
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
Genes Dev
2010
Participants
components
3' Fragment of Cleaved mRNA [cytosol]
5' Fragment of Cleaved mRNA [cytosol]
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
p-4S-UPF1 [cytosol] (Homo sapiens)
PABPC1 [cytosol] (Homo sapiens)
PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
SMG7 [cytosol] (Homo sapiens)
Participant Of
input
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
output
SMG6 hydrolyzes mRNA with premature termination codon
Inferred To
mRNA Cleaved by SMG6 [cytosol] (Arabidopsis thaliana)
mRNA Cleaved by SMG6 [cytosol] (Bos taurus)
mRNA Cleaved by SMG6 [cytosol] (Canis familiaris)
mRNA Cleaved by SMG6 [cytosol] (Drosophila melanogaster)
mRNA Cleaved by SMG6 [cytosol] (Gallus gallus)
mRNA Cleaved by SMG6 [cytosol] (Mus musculus)
mRNA Cleaved by SMG6 [cytosol] (Oryza sativa)
mRNA Cleaved by SMG6 [cytosol] (Rattus norvegicus)
mRNA Cleaved by SMG6 [cytosol] (Sus scrofa)
mRNA Cleaved by SMG6 [cytosol] (Taeniopygia guttata)
mRNA Cleaved by SMG6 [cytosol] (Xenopus tropicalis)
