Reactome | SMG6 [cytosol]

SMG6 [cytosol]

Stable Identifier

R-HSA-927851

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Telomerase-binding protein EST1A, EST1A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86US8 SMG6

Gene Names

SMG6, C17orf31, EST1A, KIAA0732

Chain

chain:1-1419

Reference Genes

BioGPS Gene:23293 SMG6

COSMIC (genes):SMG6 SMG6

CTD Gene:23293 SMG6

dbSNP Gene:23293 SMG6

ENSEMBL:ENSG00000070366 SMG6

ENSEMBL:ENSG00000070366.14 SMG6

HGNC:17809 SMG6

KEGG Gene (Homo sapiens):23293 SMG6

Monarch:23293 SMG6

NCBI Gene:23293 SMG6

OMIM:610963 SMG6

UCSC:Q86US8 SMG6

Reference Transcript

Other Identifiers

11720869_a_at

11745314_a_at

16839554

214940_PM_s_at

214940_s_at

23293

33798_at

3740837

3740839

3740840

3740841

3740842

3740849

3740853

3740855

3740865

3740869

3740870

3740901

3740906

3740907

3740924

3740925

3740932

3740936

3740941

3740942

3740943

3740944

3740945

3740946

3740948

3740949

3740954

3740955

8011222

A_23_P100676

GE56630

GO:0000184

GO:0000781

GO:0003677

GO:0003723

GO:0003824

GO:0004518

GO:0004519

GO:0004521

GO:0005515

GO:0005634

GO:0005694

GO:0005697

GO:0005730

GO:0005737

GO:0005829

GO:0006406

GO:0006913

GO:0016071

GO:0016787

GO:0032200

GO:0032204

GO:0032210

GO:0035145

GO:0035303

GO:0042162

GO:0043021

GO:0043226

GO:0046872

GO:0051972

GO:0070034

GO:0070182

GO:0090502

GO:0140098

GO:1904354

HMNXSV003000426

HMNXSV003031015

Hs.20185.1.S1_3p_a_at

ILMN_1695280

PH_hs_0026197

TC17000988.hg

Participates

as an output of

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)

as an input of

p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)

as a component of

Inferred To

SMG6 [cytosol] (Bos taurus)

SMG6 [cytosol] (Canis familiaris)

SMG6 [cytosol] (Gallus gallus)

SMG6 [cytosol] (Mus musculus)

SMG6 [cytosol] (Schizosaccharomyces pombe)

SMG6 [cytosol] (Sus scrofa)

smg-6 [cytosol] (Caenorhabditis elegans)

Smg6 [cytosol] (Drosophila melanogaster)

Smg6 [cytosol] (Rattus norvegicus)

Ghost homologue of SMG6 [cytosol] (Dictyostelium discoideum)

Ghost homologue of SMG6 [cytosol] (Plasmodium falciparum)

smg6 [cytosol] (Danio rerio)

smg6 [cytosol] (Xenopus tropicalis)

EBS1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_005256628.1, NP_001243756.1, XP_011522071.1, NP_060045.4, NP_001243757.1, XP_016879888.1, XP_011522077.1, NP_001269255.1, XP_005256626.1

OpenTargets

ENSG00000070366

HPA

ENSG00000070366-SMG6

GeneCards

Q86US8

Ensembl

ENSG00000070366, ENSP00000440283, ENST00000263073, ENST00000354901, ENSP00000263073, ENST00000536871, ENSP00000346977

PRO

Q86US8

Pharos - Targets

Q86US8

Orphanet

26216

PDB

2HWW, 2HWX, 4UM2, 2DOK

HMDB Protein

HMDBP08841

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:Q92900-2 UPF1			0.499	2
UniProt:Q9Q2G4 Q9Q2G4			0.462	2

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