Reactome | SMG6 [cytosol]

SMG6 [cytosol]

Stable Identifier

R-HSA-927851

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Telomerase-binding protein EST1A, EST1A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86US8 SMG6

Gene Names

SMG6, C17orf31, EST1A, KIAA0732

Chain

chain:1-1419

Reference Genes

BioGPS Gene:23293 SMG6

COSMIC (genes):SMG6 SMG6

CTD Gene:23293 SMG6

dbSNP Gene:23293 SMG6

ENSEMBL:ENSG00000070366 SMG6

HGNC:17809 SMG6

Monarch:23293 SMG6

NCBI Gene:23293 SMG6

OMIM:610963 SMG6

UCSC:Q86US8 SMG6

Reference Transcript

Other Identifiers

11720869_a_at

11745314_a_at

16839554

214940_PM_s_at

214940_s_at

23293

33798_at

3740837

3740839

3740840

3740841

3740842

3740843

3740844

3740849

3740853

3740854

3740855

3740861

3740862

3740863

3740865

3740866

3740868

3740869

3740870

3740873

3740874

3740875

3740876

3740877

3740896

3740897

3740898

3740899

3740900

3740901

3740902

3740906

3740907

3740919

3740924

3740925

3740926

3740927

3740932

3740936

3740941

3740942

3740943

3740944

3740945

3740946

3740948

3740949

3740954

3740955

69338_at

8011222

83681_at

A_23_P100676

GE56630

GO:0000184

GO:0000781

GO:0003677

GO:0003723

GO:0003824

GO:0004519

GO:0004521

GO:0005515

GO:0005634

GO:0005694

GO:0005697

GO:0005730

GO:0005737

GO:0005829

GO:0006406

GO:0006913

GO:0016071

GO:0016787

GO:0032204

GO:0032210

GO:0035145

GO:0035303

GO:0042162

GO:0043021

GO:0043226

GO:0046872

GO:0070034

GO:0070182

GO:0140098

GO:1904354

HMNXSV003000426

HMNXSV003031015

Hs.20185.1.S1_3p_a_at

ILMN_1695280

PH_hs_0026197

TC17000988.hg

Participates

as an output of

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)

as an input of

p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)

as a component of

Inferred To

SMG6 [cytosol] (Bos taurus)

SMG6 [cytosol] (Canis familiaris)

SMG6 [cytosol] (Gallus gallus)

SMG6 [cytosol] (Mus musculus)

SMG6 [cytosol] (Schizosaccharomyces pombe)

SMG6 [cytosol] (Sus scrofa)

smg-6 [cytosol] (Caenorhabditis elegans)

Smg6 [cytosol] (Drosophila melanogaster)

Smg6 [cytosol] (Rattus norvegicus)

Ghost homologue of SMG6 [cytosol] (Dictyostelium discoideum)

Ghost homologue of SMG6 [cytosol] (Plasmodium falciparum)

ESL2 [cytosol] (Saccharomyces cerevisiae)

EST1 [cytosol] (Saccharomyces cerevisiae)

smg6 [cytosol] (Danio rerio)

smg6 [cytosol] (Xenopus tropicalis)

EBS1 [cytosol] (Saccharomyces cerevisiae)

ESL1 [cytosol] (Saccharomyces cerevisiae)

Homologues of SMG6 [cytosol] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000070366

ENSEMBL

ENSP00000440283, ENST00000536871, ENST00000263073, ENST00000354901, ENSP00000346977, ENSP00000263073

HPA

ENSG00000070366-SMG6

PRO

Q86US8

Pharos - Targets

Q86US8

PDB

2DOK, 2HWW, 2HWX, 4UM2, 8RXB

HMDB Protein

HMDBP08841

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:A6H8Z2 F221B			0.527	2
UniProt:Q2NKX9 CB068			0.527	2
UniProt:Q9BQK8 LPIN3	3	p-S106-LPIN3 [nucleoplasm] (R-HSA-4419935) LPIN3 [nuclear envelope] (R-HSA-4419928) LPIN3 [endoplasmic reticulum membrane] (R-HSA-549160)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.527	2
UniProt:Q9NYQ3 HAO2	2	HAO2 [cytosol] (R-HSA-9033093) HAO2 [peroxisomal matrix] (R-HSA-6787806)	0.527	2
UniProt:Q92900-2 UPF1			0.499	2
UniProt:Q9Q2G4 Q9Q2G4			0.462	2

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