Reactome | p-4S-UPF1 [cytosol]

p-4S-UPF1 [cytosol]

Stable Identifier

R-HSA-927856

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UPF1 Phosphorylated at Serines 1084, 1089,1107, 1127, Regulator of nonsense transcripts 1, RENT1_HUMAN, UPF1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q92900 UPF1

Gene Names

UPF1, KIAA0221, RENT1

Chain

chain:1-1129

Reference Genes

BioGPS Gene:5976 UPF1

COSMIC (genes):UPF1 UPF1

CTD Gene:5976 UPF1

dbSNP Gene:5976 UPF1

ENSEMBL:ENSG00000005007 UPF1

HGNC:9962 UPF1

KEGG Gene (Homo sapiens):5976 UPF1

Monarch:5976 UPF1

NCBI Gene:5976 UPF1

OMIM:601430 UPF1

UCSC:Q92900 UPF1

Reference Transcript

Other Identifiers

0006200500

11717322_a_at

11754616_a_at

11754617_s_at

16859874

208947_s_at

211168_s_at

3825384

3825385

3825386

3825393

3825394

3825395

3825396

3825398

3825400

3825401

3825402

3825404

3825405

3825406

3825408

3825409

3825411

3825412

3825414

3825416

3825417

3825419

3825420

3825421

3825423

3825424

3825426

3825427

3825428

39404_s_at

5976

8027074

A_24_P194154

D86988_at

GE62804

GO:0000166

GO:0000184

GO:0000294

GO:0000781

GO:0000785

GO:0000932

GO:0000956

GO:0003674

GO:0003677

GO:0003682

GO:0003723

GO:0003724

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006260

GO:0006281

GO:0006406

GO:0006412

GO:0006449

GO:0006810

GO:0006913

GO:0006950

GO:0007049

GO:0008150

GO:0008270

GO:0009048

GO:0009056

GO:0009058

GO:0015031

GO:0016032

GO:0016787

GO:0016887

GO:0032201

GO:0032204

GO:0032991

GO:0034641

GO:0034655

GO:0035145

GO:0042162

GO:0042592

GO:0043167

GO:0043226

GO:0044403

GO:0044530

GO:0044770

GO:0046872

GO:0051276

GO:0061014

GO:0061158

GO:0071044

GO:0071222

GO:0071347

HMNXSV003007509

ILMN_1688011

PH_hs_0024447

TC19000365.hg

U65533_s_at

g1633577_3p_a_at

g1944406_3p_a_at

Participates

as a component of

This entity regulates

Positively

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)

Other forms of this molecule

UPF1 [cytosol]

Inferred To

phospho-Upf1 [cytosol] (Drosophila melanogaster)

phospho-Upf1 [cytosol] (Mus musculus)

phospho-Upf1 [cytosol] (Rattus norvegicus)

phospho-p-4S-UPF1 [cytosol] (Plasmodium falciparum)

phospho-smg-2 [cytosol] (Caenorhabditis elegans)

phospho-upf1 [cytosol] (Danio rerio)

phospho-upf1 [cytosol] (Dictyostelium discoideum)

phospho-upf1 [cytosol] (Schizosaccharomyces pombe)

phospho-UPF1 [cytosol] (Bos taurus)

phospho-UPF1 [cytosol] (Canis familiaris)

phospho-UPF1 [cytosol] (Gallus gallus)

phospho-UPF1 [cytosol] (Sus scrofa)

phospho-NAM7 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

O-phospho-L-serine at 1089

Coordinate

1089

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1107

Coordinate

1107

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1084

Coordinate

1084

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1127

Coordinate

1127

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001284478.1, NP_002902.2

OpenTargets

ENSG00000005007

GeneCards

Q92900

HPA

ENSG00000005007-UPF1

Ensembl

ENSP00000470142, ENST00000599848, ENSG00000005007, ENST00000262803, ENSP00000262803

PRO

Q92900

PDB

2XZP, 2GK6, 2GJK, 2WJY, 2XZO, 6Z3R, 2WJV, 6EJ5, 2IYK, 2GK7

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.953	29
UniProt:Q9BZI7 UPF3B	2	UPF3B [cytosol] (R-HSA-159258) UPF3B [nucleoplasm] (R-HSA-156776)	0.848	10
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.783	13
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.758	7
UniProt:O95793 STAU1			0.714	5
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.698	5
UniProt:Q09161 NCBP1	2	NCBP1 [cytosol] (R-HSA-162459) NCBP1 [nucleoplasm] (R-HSA-51469)	0.69	9
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.643	3
UniProt:Q8IU60 DCP2	1	DCP2 [cytosol] (R-HSA-429937)	0.641	3
UniProt:Q9NPJ4 PNRC2	1	PNRC2 [cytosol] (R-HSA-8879146)	0.616	9
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.576	3
UniProt:Q9UN81 LORF1			0.576	6
UniProt:Q9H1J1 UPF3A	1	UPF3A [cytosol] (R-HSA-927801)	0.564	4
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	3
UniProt:P0DTC9 N	10	phospho-SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694424) phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol] (R-COV-9694431) phospho-SUMO1-K62-ADPr-p-S177-Ncap [cytosol] (R-COV-9694558) phospho-ADPr-p-S177-Ncap [cytosol] (R-COV-9694254) phospho-p-S177-Ncap [cytosol] (R-COV-9694472) Ncap [cytosol] (R-COV-9694300) Ncap [plasma membrane] (R-COV-9694356) phospho-SUMO1-K62-ADPr-p-S177-Ncap [nucleolus] (R-COV-9694318) phospho-SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane] (R-COV-9694764) N [cytosol] (R-COV-9694314)	0.527	2
UniProt:P03496 NS	2	NS1 [cytosol] (R-FLU-169118) NS1 [nucleoplasm] (R-FLU-169113)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.524	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.524	3
UniProt:P55265 ADAR	1	ADAR [nucleoplasm] (R-HSA-53939)	0.524	3
UniProt:Q92540 SMG7	1	SMG7 [cytosol] (R-HSA-927838)	0.499	3
UniProt:Q14493 SLBP	2	SLBP [nucleoplasm] (R-HSA-64547) SLBP [cytosol] (R-HSA-141613)	0.499	3
UniProt:Q9BZI7-2 UPF3B			0.488	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.462	3

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