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SMG5 [cytosol]
Stable Identifier
R-HSA-927867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein SMG5, SMG5_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
SMG5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPR3 SMG5
Gene Names
SMG5, EST1B, KIAA1089
Chain
initiator methionine:1, chain:2-1016
Reference Genes
BioGPS Gene:23381 SMG5
COSMIC (genes):SMG5 SMG5
CTD Gene:23381 SMG5
dbSNP Gene:23381 SMG5
ENSEMBL:ENSG00000198952 SMG5
HGNC:24644 SMG5
KEGG Gene (Homo sapiens):23381 SMG5
Monarch:23381 SMG5
NCBI Gene:23381 SMG5
OMIM:610962 SMG5
UCSC:Q9UPR3 SMG5
Reference Transcript
RefSeq:NM_015327.2 SMG5
Other Identifiers
0004120672
11744154_x_at
16694472
212147_at
23381
2438040
2438041
2438043
2438044
2438045
2438046
2438047
2438048
2438049
2438051
2438054
2438055
2438057
2438058
2438063
2438064
2438065
2438066
2438067
2438068
2438069
2438070
2438071
2438073
2438074
2438075
2438077
2438079
2438082
2438086
2438088
2438089
2438090
2438091
2438092
34868_at
57060_at
57063_g_at
64284_f_at
7920944
A_23_P322043
A_33_P3326349
GE53740
GE86761
GO:0000184
GO:0003674
GO:0003677
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005697
GO:0005737
GO:0005829
GO:0006259
GO:0006406
GO:0006810
GO:0006913
GO:0007004
GO:0008150
GO:0009056
GO:0009058
GO:0015031
GO:0019899
GO:0031625
GO:0032204
GO:0032210
GO:0032991
GO:0034641
GO:0034655
GO:0035303
GO:0042162
GO:0042592
GO:0042826
GO:0043226
GO:0051276
GO:0051721
GO:0070034
Hs.4990.0.A1_3p_s_at
ILMN_1721735
ILMN_2126239
PH_hs_0025367
TC01003334.hg
Participant Of
output
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
input
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
hasComponent
mRNA Cleaved by SMG6 [cytosol]
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
Inferred To
Smg5 [cytosol] (Drosophila melanogaster)
Smg5 [cytosol] (Mus musculus)
Smg5 [cytosol] (Rattus norvegicus)
Homologues of SMG5 [cytosol] (Saccharomyces cerevisiae)
SMG5 [cytosol] (Bos taurus)
SMG5 [cytosol] (Canis familiaris)
SMG5 [cytosol] (Gallus gallus)
SMG5 [cytosol] (Schizosaccharomyces pombe)
SMG5 [cytosol] (Sus scrofa)
SMG5 [cytosol] (Xenopus tropicalis)
ESL2 [cytosol] (Saccharomyces cerevisiae)
EST1 [cytosol] (Saccharomyces cerevisiae)
smg5 [cytosol] (Danio rerio)
Ghost homologue of SMG5 [cytosol] (Caenorhabditis elegans)
Ghost homologue of SMG5 [cytosol] (Dictyostelium discoideum)
Ghost homologue of SMG5 [cytosol] (Plasmodium falciparum)
EBS1 [cytosol] (Saccharomyces cerevisiae)
ESL1 [cytosol] (Saccharomyces cerevisiae)
Cross References
RefSeq
NP_056142.2
OpenTargets
ENSG00000198952
HPA
ENSG00000198952-SMG5
GeneCards
Q9UPR3
Ensembl
ENST00000361813
,
ENSP00000355261
,
ENSG00000198952
PRO
Q9UPR3
PDB
2HWY
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.527
2
UniProt:Q92540 SMG7
1
SMG7 [cytosol]
(R-HSA-927838)
0.499
5
UniProt:Q92900-2 UPF1
0.499
2
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