Reactome | SMG5 [cytosol]

SMG5 [cytosol]

Stable Identifier

R-HSA-927867

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein SMG5, SMG5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UPR3 SMG5

Gene Names

SMG5, EST1B, KIAA1089

Chain

initiator methionine:1, chain:2-1016

Reference Genes

BioGPS Gene:23381 SMG5

COSMIC (genes):SMG5 SMG5

CTD Gene:23381 SMG5

dbSNP Gene:23381 SMG5

ENSEMBL:ENSG00000198952 SMG5

HGNC:24644 SMG5

KEGG Gene (Homo sapiens):23381 SMG5

Monarch:23381 SMG5

NCBI Gene:23381 SMG5

OMIM:610962 SMG5

UCSC:Q9UPR3 SMG5

Reference Transcript

RefSeq:NM_015327.2 SMG5

Other Identifiers

0004120672

11744154_x_at

16694472

212147_at

23381

2438040

2438041

2438043

2438044

2438045

2438046

2438047

2438048

2438049

2438051

2438054

2438055

2438057

2438058

2438063

2438064

2438065

2438066

2438067

2438068

2438069

2438070

2438071

2438073

2438074

2438075

2438077

2438079

2438082

2438086

2438088

2438089

2438090

2438091

2438092

34868_at

57060_at

57063_g_at

64284_f_at

7920944

A_23_P322043

A_33_P3326349

GE53740

GE86761

GO:0000184

GO:0003674

GO:0003677

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005697

GO:0005737

GO:0005829

GO:0006259

GO:0006406

GO:0006810

GO:0006913

GO:0007004

GO:0008150

GO:0009056

GO:0009058

GO:0015031

GO:0019899

GO:0031625

GO:0032204

GO:0032210

GO:0032991

GO:0034641

GO:0034655

GO:0035303

GO:0042162

GO:0042592

GO:0042826

GO:0043226

GO:0051276

GO:0051721

GO:0070034

Hs.4990.0.A1_3p_s_at

ILMN_1721735

ILMN_2126239

PH_hs_0025367

TC01003334.hg

Participant Of

output

Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex

input

p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A

hasComponent

Inferred To

Smg5 [cytosol] (Drosophila melanogaster)

Smg5 [cytosol] (Mus musculus)

Smg5 [cytosol] (Rattus norvegicus)

Homologues of SMG5 [cytosol] (Saccharomyces cerevisiae)

SMG5 [cytosol] (Bos taurus)

SMG5 [cytosol] (Canis familiaris)

SMG5 [cytosol] (Gallus gallus)

SMG5 [cytosol] (Schizosaccharomyces pombe)

SMG5 [cytosol] (Sus scrofa)

SMG5 [cytosol] (Xenopus tropicalis)

ESL2 [cytosol] (Saccharomyces cerevisiae)

EST1 [cytosol] (Saccharomyces cerevisiae)

smg5 [cytosol] (Danio rerio)

Ghost homologue of SMG5 [cytosol] (Caenorhabditis elegans)

Ghost homologue of SMG5 [cytosol] (Dictyostelium discoideum)

Ghost homologue of SMG5 [cytosol] (Plasmodium falciparum)

EBS1 [cytosol] (Saccharomyces cerevisiae)

ESL1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_056142.2

OpenTargets

ENSG00000198952

HPA

ENSG00000198952-SMG5

GeneCards

Q9UPR3

Ensembl

ENSG00000198952, ENSP00000355261, ENST00000361813

PRO

Q9UPR3

PDB

2HWY

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.527	2
UniProt:Q92540 SMG7	1	SMG7 [cytosol] (R-HSA-927838)	0.499	5
UniProt:Q92900-2 UPF1			0.499	2

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