Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CASP10(1-521) [cytosol]
Stable Identifier
R-HSA-933453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Caspase-10 precursor , ICE-like apoptotic protease 4, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 stimulates CASP10 expression (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 (Homo sapiens)
Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)
CASP8(1-479), CASP10(1-521) [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
procaspase-8/10 dimer [cytosol] (Homo sapiens)
procaspase-10 dimer [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
CASP8(1-479), CASP10(1-521) [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
Processing of caspases (Homo sapiens)
procaspase-8/10 dimer [cytosol] (Homo sapiens)
procaspase-10 dimer [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
procaspase-8/10 dimer [cytosol] (Homo sapiens)
procaspase-10 dimer [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)
CASP8(1-479), CASP10(1-521) [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:CASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
CASP8(1-479), CASP10(1-521) [cytosol] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
FasL/ CD95L signaling (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
TRAIL signaling (Homo sapiens)
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP10(1-521) [plasma membrane] (Homo sapiens)
CASP10(1-521) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92851 CASP10
Gene Names
CASP10, MCH4
Chain
propeptide:1-219, chain:220-415, chain:416-521
Reference Genes
BioGPS Gene:843 CASP10
COSMIC (genes):CASP10 CASP10
CTD Gene:843 CASP10
dbSNP Gene:843 CASP10
ENSEMBL:ENSG00000003400 CASP10
HGNC:1500 CASP10
KEGG:hsa:843 CASP10
Monarch:843 CASP10
NCBI Gene:843 CASP10
OMIM:601762 CASP10
UCSC:Q92851 CASP10
Reference Transcript
RefSeq:NM_032976.3 CASP10
RefSeq:NM_001230.4 CASP10
RefSeq:NM_032974.4 CASP10
RefSeq:NM_001206524.1 CASP10
RefSeq:NM_032977.3 CASP10
RefSeq:NM_001206542.1 CASP10
RefSeq:NM_001306083.1 CASP10
Participates
as a component of
TNFSF10:TNFRSF10A,B:FADD:CASP10(1-521) [plasma membrane] (Homo sapiens)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane] (Homo sapiens)
procaspase-10 dimer [cytosol] (Homo sapiens)
as an input of
TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Homo sapiens)
as an output of
TP53 stimulates CASP10 expression (Homo sapiens)
as a member of
CASP8(1-479), CASP10(1-521) [cytosol] (Homo sapiens)
Other forms of this molecule
CASP10(416-521) [cytosol]
CASP10(1-219) [cytosol]
CASP10(220-415) [cytosol]
Inferred To
CASP10(1-521) [cytosol]
(Gallus gallus)
CASP10(1-521) [cytosol]
(Sus scrofa)
casp10 [cytosol]
(Danio rerio)
Cross References
Guide to Pharmacology - Targets
1626
OpenTargets
ENSG00000003400
ENSEMBL
ENSP00000237865
,
ENSP00000512459
,
ENSP00000363781
,
ENSG00000003400
,
ENSP00000286186
,
ENST00000313728
,
ENSP00000272879
,
ENST00000374650
,
ENST00000346817
,
ENST00000492363
,
ENST00000448480
,
ENSP00000314599
,
ENSP00000396835
,
ENST00000272879
,
ENST00000286186
IntEnz
3.4.22.63
HPA
ENSG00000003400-CASP10
GeneCards
CASP10
ZINC - Substances
CASPA_HUMAN
ZINC target
Q92851
PRO
Q92851
Pharos - Targets
Q92851
Orphanet
CASP10
ZINC - Predictions - Purchasable
CASPA_HUMAN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.75
4
UniProt:Q14790 CASP8
8
CASP8(1-479) [cytosol]
(R-HSA-57031)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(1-374) [cytosol]
(R-HSA-3465404)
0.734
6
UniProt:O14730 RIOK3
1
RIOK3 [cytosol]
(R-HSA-6791522)
0.725
6
UniProt:O15519 CFLAR
1
CFLAR(1-376) [cytosol]
(R-HSA-51925)
0.65
3
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text