Translocation of p-IRF7:p-IRF7 to nucleus

Stable Identifier
R-HSA-933531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
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Translocation of p-IRF7:p-IRF7 to nucleus
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p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

Literature References
PubMed ID Title Journal Year
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Marié, I, Smith, E, Prakash, A, Levy, DE

Mol Cell Biol 2000
Participants
Input
Output
Participant Of
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Orthologous Events
Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)
Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)
Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)
Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)
Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)
Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Jin, L  (2013-05-22)
Wu, J  (2013-05-22)
Created
Garapati, P V  (2010-08-16)
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