Translocation of p-IRF7:p-IRF7 to nucleus

Stable Identifier
R-HSA-933531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
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Translocation of p-IRF7:p-IRF7 to nucleus
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p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

Literature References
PubMed ID Title Journal Year
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Marié, I, Prakash, A, Smith, E, Levy, DE

Mol Cell Biol 2000
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
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Orthologous Events
Translocation of p-IRF7:p-IRF7 to nucleus (Bos taurus)
Translocation of p-IRF7:p-IRF7 to nucleus (Danio rerio)
Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)
Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)
Translocation of p-IRF7:p-IRF7 to nucleus (Rattus norvegicus)
Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)
Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
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