Dimerization of p-IRF7

Stable Identifier
R-HSA-933533
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylation stimulates the C-terminal autoinhibitory domain of IRF7 to attain a highly extended conformation triggering dimerization through extensive contacts to a second IRF7 subunit.
Literature References
PubMed ID Title Journal Year
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

MariƩ, I, Prakash, A, Smith, E, Levy, DE

Mol Cell Biol 2000
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
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