Reactome | TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation

Stable Identifier

R-HSA-933541

Type

Pathway

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

TRAF6 is crucial for both DDX58 (RIG-I)- and IFIH1 (MDA5)-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL6 after infection with RNA virus. Activation of NF-kB and IRF7, but not that of IRF3, was significantly impaired during RIG-like helicases (RLHs) signaling in the absence of TRAF6. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7. These results strongly suggest that the TRAF6- and TRAF3-dependent pathways are likely to bifurcate at mitochondrial antiviral-signaling protein MAVS (IPS-1), but to converge later at IRF7 in order to co-operatively induce sufficient production of type I IFNs during RLH signaling.

Literature References

PubMed ID	Title	Journal	Year
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T	PLoS One	2009