TRAF6 mediated NF-kB activation

Stable Identifier
R-HSA-933542
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Pathway
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Homo sapiens
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The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs.

Literature References
PubMed ID Title Journal Year
18984593 TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

Yoshida, R, Takaesu, G, Yoshida, H, Okamoto, F, Yoshioka, T, Choi, Y, Akira, S, Kawai, T, Yoshimura, A, Kobayashi, T

J Biol Chem 2008
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