Reactome | UBE2L6 [cytosol]

UBE2L6 [cytosol]

Stable Identifier

R-HSA-936014

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBCH8, Ubiquitin/ISG15-conjugating enzyme E2 L6, UB2L6_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9BZR9 TRIM8

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External Reference Information

External Reference

UniProt:O14933 UBE2L6

Gene Names

UBE2L6, UBCH8

Chain

chain:1-153

Reference Genes

BioGPS Gene:9246 UBE2L6

COSMIC (genes):UBE2L6 UBE2L6

CTD Gene:9246 UBE2L6

dbSNP Gene:9246 UBE2L6

ENSEMBL:ENSG00000156587 UBE2L6

HGNC:12490 UBE2L6

KEGG Gene (Homo sapiens):9246 UBE2L6

Monarch:9246 UBE2L6

NCBI Gene:9246 UBE2L6

OMIM:603890 UBE2L6

UCSC:O14933 UBE2L6

Reference Transcript

Other Identifiers

0001170300

0003130162

0005720270

0103130044

11721994_s_at

16738544

201649_at

3373963

3373964

3373965

3373966

3373967

3373972

3373973

3373976

3373977

3373980

3373981

3373982

3373983

40505_at

75081_r_at

7948274

9246

A_23_P75741

GE54567

GO:0000151

GO:0000209

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006464

GO:0006511

GO:0006950

GO:0008150

GO:0009056

GO:0009058

GO:0016567

GO:0016740

GO:0019787

GO:0019899

GO:0019941

GO:0019985

GO:0031625

GO:0032020

GO:0032182

GO:0032480

GO:0032991

GO:0034641

GO:0042296

GO:0043130

GO:0043226

GO:0044267

GO:0061631

ILMN_1703108

ILMN_1769520

ILMN_1778698

ILMN_2252495

PH_hs_0030146

TC11001795.hg

g4759281_3p_at

Participant Of

hasComponent

output

input

Transfer of ISG15 from E1 to E2 (UBCH8)

hasCandidate

hasMember

E2 enzymes UbcH8/UBE1L [cytosol]

Other forms of this molecule

UBE2L6 [nucleoplasm]

Inferred To

Dmel\CG17030 [cytosol] (Drosophila melanogaster)

Homologues of UBE2L6 [cytosol] (Danio rerio)

Homologues of UBE2L6 [cytosol] (Dictyostelium discoideum)

Homologues of UBE2L6 [cytosol] (Drosophila melanogaster)

Homologues of UBE2L6 [cytosol] (Plasmodium falciparum)

ube2l3a [cytosol] (Danio rerio)

Ubc10 [cytosol] (Drosophila melanogaster)

ube2l3b [cytosol] (Danio rerio)

Ubc84D [cytosol] (Drosophila melanogaster)

UBE2L6 [cytosol] (Bos taurus)

UBE2L6 [cytosol] (Canis familiaris)

UBE2L6 [cytosol] (Dictyostelium discoideum)

UBE2L6 [cytosol] (Plasmodium falciparum)

UBE2L6 [cytosol] (Sus scrofa)

UBE2L6 [cytosol] (Xenopus tropicalis)

ubc14 [cytosol] (Schizosaccharomyces pombe)

UBE2L3 [cytosol] (Gallus gallus)

Ube2l6 [cytosol] (Mus musculus)

Ube2l6 [cytosol] (Rattus norvegicus)

ubc-18 [cytosol] (Caenorhabditis elegans)

ubcB [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_937826.1, NP_004214.1

OpenTargets

ENSG00000156587

HPA

ENSG00000156587-UBE2L6

GeneCards

O14933

Ensembl

ENSG00000156587, ENSP00000341980, ENSP00000287156, ENST00000340573, ENST00000287156

PRO

O14933

HMDB Protein

HMDBP00564

PDB

2KJH, 1WZV, 1WZW

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.841	13
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.781	7
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.781	7
UniProt:Q7Z419 RNF144B	1	RNF144B [cytosol] (R-HSA-975988)	0.681	4
UniProt:Q8N9I9 DTX3			0.666	6
UniProt:Q9BZR9 TRIM8	1	TRIM8 [cytosol] (R-HSA-5624332)	0.666	4
UniProt:Q99732 LITAF			0.556	3
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.556	3
IntAct:EBI-23192465 CCSB ORF ID			0.556	5
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:P62879 GNB2	4	Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335) Partially folded GNB2 [cytosol] (R-HSA-8850536) GNB2 [cytosol] (R-HSA-6814421)	0.556	3
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.556	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.524	3
UniProt:Q8CJB9	1	Rnf40 [nucleoplasm] (R-RNO-5689015)	0.499	2
UniProt:Q99PZ6 OSPG			0.499	2
UniProt:Q96EQ8 RNF125	2	K48polyUb-RNF125 [cytosol] (R-HSA-3080560) RNF125 [cytosol] (R-HSA-918184)	0.488	2
UniProt:P21605 E3			0.463	2

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