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UBE2L6 [cytosol]
Stable Identifier
R-HSA-936014
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBCH8, Ubiquitin/ISG15-conjugating enzyme E2 L6, UB2L6_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9BZR9 TRIM8
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
ISGylation of E2 conjugating enzymes (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
ISGylation of IRF3 (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
ISGylation of host protein filamin B (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
ISGylation of host proteins (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
ISGylation of viral protein NS1 (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)
UBE2L6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14933 UBE2L6
Gene Names
UBE2L6, UBCH8
Chain
chain:1-153
Reference Genes
BioGPS Gene:9246 UBE2L6
COSMIC (genes):UBE2L6 UBE2L6
CTD Gene:9246 UBE2L6
dbSNP Gene:9246 UBE2L6
ENSEMBL:ENSG00000156587 UBE2L6
HGNC:12490 UBE2L6
KEGG Gene (Homo sapiens):9246 UBE2L6
Monarch:9246 UBE2L6
NCBI Gene:9246 UBE2L6
OMIM:603890 UBE2L6
UCSC:O14933 UBE2L6
Reference Transcript
RefSeq:NM_004223.4 UBE2L6
RefSeq:NM_198183.2 UBE2L6
Other Identifiers
0001170300
0003130162
0005720270
0103130044
11721994_s_at
16738544
201649_at
3373963
3373964
3373965
3373966
3373967
3373972
3373973
3373976
3373977
3373980
3373981
3373982
3373983
40505_at
75081_r_at
7948274
9246
A_23_P75741
GE54567
GO:0000151
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006464
GO:0006511
GO:0006950
GO:0008150
GO:0009056
GO:0009058
GO:0016567
GO:0016740
GO:0019787
GO:0019899
GO:0019941
GO:0019985
GO:0031625
GO:0032020
GO:0032182
GO:0032480
GO:0032991
GO:0034641
GO:0042296
GO:0043130
GO:0043226
GO:0044267
GO:0061631
ILMN_1703108
ILMN_1769520
ILMN_1778698
ILMN_2252495
PH_hs_0030146
TC11001795.hg
g4759281_3p_at
Participant Of
hasComponent
ISG15:UBCH8 [cytosol]
SIAH1:UBE2L6:Ub-SNCA [cytosol]
UBE2L6:Ubiquitin [cytosol]
output
ISGylation of E2 conjugating enzymes
ISGylation of host protein filamin B
ISGylation of host proteins
ISGylation of IRF3
ISGylation of protein phosphatase 1 beta (PP2CB)
ISGylation of viral protein NS1
Ub-SNCA dissociates from the conjugating enzyme
input
Transfer of ISG15 from E1 to E2 (UBCH8)
hasCandidate
E2 enzyme (UBE2K, UbcH5a-c) [cytosol]
E2 Ubiquitin-conjugating enzyme [cytosol]
hasMember
E2 enzymes UbcH8/UBE1L [cytosol]
Other forms of this molecule
UBE2L6 [nucleoplasm]
Inferred To
Dmel\CG17030 [cytosol] (Drosophila melanogaster)
Homologues of UBE2L6 [cytosol] (Danio rerio)
Homologues of UBE2L6 [cytosol] (Dictyostelium discoideum)
Homologues of UBE2L6 [cytosol] (Drosophila melanogaster)
Homologues of UBE2L6 [cytosol] (Plasmodium falciparum)
ube2l3a [cytosol] (Danio rerio)
Ubc10 [cytosol] (Drosophila melanogaster)
ube2l3b [cytosol] (Danio rerio)
Ubc84D [cytosol] (Drosophila melanogaster)
UBE2L6 [cytosol] (Bos taurus)
UBE2L6 [cytosol] (Canis familiaris)
UBE2L6 [cytosol] (Dictyostelium discoideum)
UBE2L6 [cytosol] (Plasmodium falciparum)
UBE2L6 [cytosol] (Sus scrofa)
UBE2L6 [cytosol] (Xenopus tropicalis)
ubc14 [cytosol] (Schizosaccharomyces pombe)
UBE2L3 [cytosol] (Gallus gallus)
Ube2l6 [cytosol] (Mus musculus)
Ube2l6 [cytosol] (Rattus norvegicus)
ubc-18 [cytosol] (Caenorhabditis elegans)
ubcB [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_937826.1
,
NP_004214.1
OpenTargets
ENSG00000156587
HPA
ENSG00000156587-UBE2L6
GeneCards
O14933
Ensembl
ENSG00000156587
,
ENSP00000341980
,
ENSP00000287156
,
ENST00000340573
,
ENST00000287156
PRO
O14933
HMDB Protein
HMDBP00564
PDB
2KJH
,
1WZV
,
1WZW
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95376 ARIH2
1
ARIH2 [cytosol]
(R-HSA-975987)
0.841
13
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.781
7
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.781
7
UniProt:Q7Z419 RNF144B
1
RNF144B [cytosol]
(R-HSA-975988)
0.681
4
UniProt:Q8N9I9 DTX3
0.666
6
UniProt:Q9BZR9 TRIM8
1
TRIM8 [cytosol]
(R-HSA-5624332)
0.666
4
UniProt:Q99732 LITAF
0.556
3
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.556
3
IntAct:EBI-23192465 CCSB ORF ID
0.556
5
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:P62879 GNB2
4
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
GNB2 [cytosol]
(R-HSA-6814421)
0.556
3
UniProt:Q9NWF9 RNF216
1
RNF216 [cytosol]
(R-HSA-936043)
0.556
3
UniProt:Q6ZMZ0 RNF19B
1
RNF19B [cytosol]
(R-HSA-975969)
0.524
3
UniProt:Q8CJB9
1
Rnf40 [nucleoplasm]
(R-RNO-5689015)
0.499
2
UniProt:Q99PZ6 OSPG
0.499
2
UniProt:Q96EQ8 RNF125
2
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
RNF125 [cytosol]
(R-HSA-918184)
0.488
2
UniProt:P21605 E3
0.463
2
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