Reactome | UBE2L6 [cytosol]

UBE2L6 [cytosol]

Stable Identifier

R-HSA-936014

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBCH8, Ubiquitin/ISG15-conjugating enzyme E2 L6, UB2L6_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9BZR9 TRIM8

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External Reference Information

External Reference

UniProt:O14933 UBE2L6

Gene Names

UBE2L6, UBCH8

Chain

chain:1-153

Reference Genes

BioGPS Gene:9246 UBE2L6

COSMIC (genes):UBE2L6 UBE2L6

CTD Gene:9246 UBE2L6

dbSNP Gene:9246 UBE2L6

ENSEMBL:ENSG00000156587 UBE2L6

HGNC:12490 UBE2L6

KEGG Gene (Homo sapiens):9246 UBE2L6

Monarch:9246 UBE2L6

NCBI Gene:9246 UBE2L6

OMIM:603890 UBE2L6

UCSC:O14933 UBE2L6

Reference Transcript

Other Identifiers

0001170300

0003130162

0005720270

0103130044

11721994_s_at

16738544

1WZV

1WZW

201649_at

2KJH

3328

3373963

3373964

3373965

3373966

3373967

3373972

3373973

3373976

3373977

3373980

3373981

3373982

3373983

40505_at

73407

75081_r_at

7948274

9246

A_23_P75741

AAB86433

AAD17525

AAH32491

AF031141

AF061736

AJ243268

AJ243269

AJ243270

AJ243271

AK226165

AK315755

AP002893

BAG38109

BC032491

CAB073407

CAB64566

CAG33407

CCDS7960

CCDS7961

CH471076

CR457126

E9PKW8

E9PQT7

EAW73757

EAW73759

ENSG00000156587

ENSP00000287156

ENSP00000341980

ENST00000287156

ENST00000287156.8

ENST00000340573

ENST00000340573.8

EntrezGene:9246

EntrezGene:UBE2L6

g4759281_3p_at

GE54567

GO:0000151

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006464

GO:0006511

GO:0006950

GO:0008150

GO:0009056

GO:0009058

GO:0016567

GO:0016740

GO:0019787

GO:0019899

GO:0019941

GO:0019985

GO:0031625

GO:0032020

GO:0032182

GO:0032480

GO:0032991

GO:0034641

GO:0042296

GO:0043130

GO:0043226

GO:0044267

GO:0061631

HGNC:12490

HPA003328

ILMN_1703108

ILMN_1769520

ILMN_1778698

ILMN_2252495

IPR000608

IPR016135

IPR023313

MIM:603890

NM_004223

NM_198183

NP_004214

NP_937826

PF00179

PH_hs_0030146

SM00212

TC11001795.hg

UBE2L6

UBE2L6-201

UBE2L6-202

UPI00000712E4

UPI0000213DB5

Participant Of

hasComponent

output

input

Transfer of ISG15 from E1 to E2 (UBCH8)

hasCandidate

hasMember

E2 enzymes UbcH8/UBE1L [cytosol]

Other forms of this molecule

UBE2L6 [nucleoplasm]

Inferred To

Homologues of UBE2L6 [cytosol] (Danio rerio)

Homologues of UBE2L6 [cytosol] (Dictyostelium discoideum)

Homologues of UBE2L6 [cytosol] (Drosophila melanogaster)

UBE2L6 [cytosol] (Bos taurus)

UBE2L6 [cytosol] (Caenorhabditis elegans)

UBE2L6 [cytosol] (Canis familiaris)

UBE2L6 [cytosol] (Danio rerio)

UBE2L6 [cytosol] (Dictyostelium discoideum)

UBE2L6 [cytosol] (Drosophila melanogaster)

UBE2L6 [cytosol] (Gallus gallus)

UBE2L6 [cytosol] (Mus musculus)

UBE2L6 [cytosol] (Plasmodium falciparum)

UBE2L6 [cytosol] (Rattus norvegicus)

UBE2L6 [cytosol] (Saccharomyces cerevisiae)

UBE2L6 [cytosol] (Sus scrofa)

UBE2L6 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_937826.1, NP_004214.1

OpenTargets

ENSG00000156587

GeneCards

O14933

PRO

O14933

PDB

1WZW, 1WZV, 2KJH

HMDB Protein

HMDBP00564

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.83	12
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.764	6
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.764	6
UniProt:Q7Z419 RNF144B	1	RNF144B [cytosol] (R-HSA-975988)	0.681	4
UniProt:Q8N9I9 DTX3			0.621	3
UniProt:Q9BZR9 TRIM8	1	TRIM8 [cytosol] (R-HSA-5624332)	0.621	3
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.524	3
UniProt:Q8CJB9	1	RNF40 [nucleoplasm] (R-RNO-5689015)	0.499	2
UniProt:Q99PZ6 OSPG			0.499	2
UniProt:Q05086-3 UBE3A			0.488	2
IntAct:EBI-12822247 RNF125			0.488	2
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.488	2
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.488	2
UniProt:Q96EQ8 RNF125	2	K48polyUb-RNF125 [cytosol] (R-HSA-3080560) RNF125 [cytosol] (R-HSA-918184)	0.488	2
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.488	2
UniProt:P21605 E3			0.463	2