Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PIN1 [nucleoplasm]
Stable Identifier
R-HSA-936016
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PIN1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
PI5P Regulates TP53 Acetylation (Homo sapiens)
PIN1 binds phosphorylated PIP4K2B (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-S326-PIP4K2B dimers:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
HIPK2 phosphorylates TP53 (Homo sapiens)
TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
p-HIPK2:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-HIPK2:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
TP53INP1 and HIPK2 bind TP53 (Homo sapiens)
TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
p-HIPK2:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-HIPK2:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-IRF3 dimer:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
Interaction of PIN1 with p-IRF3 (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-IRF3 dimer:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
p-IRF3 dimer:PIN1 [nucleoplasm] (Homo sapiens)
PIN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13526 PIN1
Gene Names
PIN1
Chain
chain:1-163
Reference Genes
BioGPS Gene:5300 PIN1
COSMIC (genes):PIN1 PIN1
CTD Gene:5300 PIN1
dbSNP Gene:5300 PIN1
ENSEMBL:ENSG00000127445 PIN1
ENSEMBL_homo_sapiens_GENE:ENSG00000127445.14 PIN1
HGNC:8988 PIN1
KEGG Gene (Homo sapiens):5300 PIN1
Monarch:5300 PIN1
NCBI Gene:5300 PIN1
OMIM:601052 PIN1
UCSC:Q13526 PIN1
Reference Transcript
RefSeq:NM_006221.3 PIN1
Other Identifiers
11744155_x_at
11751059_x_at
202927_3p_at
202927_PM_at
202927_at
3820179
3820189
3820196
3820201
3820202
3820203
3820204
40421_at
5300
8025506
A_23_P67162
A_33_P3210168
GE59199
GO:0000278
GO:0000413
GO:0000910
GO:0001666
GO:0001932
GO:0001934
GO:0003755
GO:0003774
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005929
GO:0006351
GO:0006355
GO:0007049
GO:0007088
GO:0008013
GO:0008092
GO:0010468
GO:0016607
GO:0016853
GO:0016859
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030496
GO:0030512
GO:0031434
GO:0031647
GO:0032091
GO:0032092
GO:0032465
GO:0032794
GO:0034330
GO:0035307
GO:0036064
GO:0036211
GO:0042177
GO:0043226
GO:0043547
GO:0045944
GO:0048156
GO:0048856
GO:0048870
GO:0050808
GO:0050815
GO:0050816
GO:0050821
GO:0051171
GO:0051219
GO:0060255
GO:0060392
GO:0070373
GO:0080090
GO:0090263
GO:0098772
GO:0098978
GO:0099524
GO:0140014
GO:0140096
GO:1900180
GO:1902430
GO:1990757
GO:2000146
HMNXSV003001271
ILMN_1776375
PH_hs_0033354
TC19001974.hg
U49070_at
g5453897_3p_at
g5453897_3p_s_at
g5453897_3p_x_at
Participates
as a component of
p-S326-PIP4K2B dimers:PIN1 [nucleoplasm] (Homo sapiens)
p-HIPK2:PIN1 [nucleoplasm] (Homo sapiens)
p-IRF3 dimer:PIN1 [nucleoplasm] (Homo sapiens)
as an input of
PIN1 binds phosphorylated PIP4K2B (Homo sapiens)
Interaction of PIN1 with p-IRF3 (Homo sapiens)
as an output of
PIN1 mediated IRF3 degradation (Homo sapiens)
Other forms of this molecule
PIN1 [cytosol]
Inferred To
PIN1 [nucleoplasm]
(Bos taurus)
PIN1 [nucleoplasm]
(Canis familiaris)
PIN1 [nucleoplasm]
(Gallus gallus)
PIN1 [nucleoplasm]
(Sus scrofa)
pinn-1 [nucleoplasm]
(Caenorhabditis elegans)
pinA [nucleoplasm]
(Dictyostelium discoideum)
dod [nucleoplasm]
(Drosophila melanogaster)
Pin1 [nucleoplasm]
(Mus musculus)
Pin1 [nucleoplasm]
(Rattus norvegicus)
ESS1 [nucleoplasm]
(Saccharomyces cerevisiae)
pin1 [nucleoplasm]
(Danio rerio)
pin1 [nucleoplasm]
(Schizosaccharomyces pombe)
pin1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006212.1
Guide to Pharmacology - Targets
3171
OpenTargets
ENSG00000127445
ZINC - Substances
PIN1_HUMAN
ZINC target
Q13526
PRO
Q13526
PDB
5B3Y
,
7SUQ
,
6O33
,
7NIF
,
2ZR4
,
3KAB
,
7BGR
,
1F8A
,
5B3Z
,
2M9J
,
2ZR5
,
1NMV
,
5VTI
,
1NMW
,
1I6C
,
3NTP
,
1PIN
,
5B3W
,
6VAJ
,
7NRK
,
5BMY
,
2ZQS
,
7F0M
,
3JYJ
,
2M9E
,
3TDB
,
3KCE
,
7NIG
,
7EFJ
,
2M9F
,
7BGV
,
3I6C
,
3KAC
,
2ZR6
,
6SVC
,
2F21
,
7BGW
,
3IKD
,
5VTK
,
2N1O
,
2LB3
,
7EKV
,
5UY9
,
6DUN
,
3IKG
,
3ODK
,
1ZCN
,
5VTJ
,
4GWT
,
7SUR
,
4GWV
,
2XPB
,
7NJ6
,
7EFX
,
7AZ2
,
8C2G
,
2M9I
,
2M8I
,
7OQ9
,
6O34
,
3TC5
,
2RUD
,
7BDP
,
3KAD
,
2M8J
,
7OQA
,
1I8G
,
2RUQ
,
2Q5A
,
4TYO
,
3TCZ
,
6SVH
,
6SVE
,
7AZ1
,
2ZQT
,
4TNS
,
7BGQ
,
2XP3
,
2KBU
,
2ZQV
,
2XP4
,
5B3X
,
2ZQU
,
7NRL
,
3OOB
,
7AXN
,
4U85
,
4QIB
,
2XP5
,
2RUC
,
4U86
,
4U84
,
5GPH
,
2XP7
,
7BDT
,
2KCF
,
2XP6
,
2ITK
,
7BG3
,
3IK8
,
2XP9
,
7BFW
,
7BDY
,
3KAF
,
2XP8
,
7NJ8
,
7AYF
,
3WH0
,
8C3C
,
3KAG
,
2RUR
,
7AOG
,
1I8H
,
2XPA
,
3KAI
,
7NJA
,
7SA5
,
3KAH
IntEnz
5.2.1.8
GeneCards
Q13526
HPA
ENSG00000127445-PIN1
Ensembl
ENST00000247970
,
ENSG00000127445
,
ENST00000588695
,
ENSP00000247970
,
ENSP00000466962
Pharos - Targets
Q13526
ZINC - Predictions - Purchasable
PIN1_HUMAN
Interactors (161)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.846
14
UniProt:Q9Y3Q8 T22D4
0.781
7
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.781
7
UniProt:Q99750 MDFI
0.781
7
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.781
7
UniProt:Q9BWW4 SSBP3
0.718
6
UniProt:P37198 NUP62
2
NUP62 [cytosol]
(R-HSA-9634226)
NUP62 [nuclear envelope]
(R-HSA-157713)
0.718
6
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.718
6
UniProt:Q969H4 CNKSR1
1
CNKSR1 [cytosol]
(R-HSA-5672629)
0.718
6
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:Q52MB2 CC184
0.718
6
UniProt:Q9NWS9-2 ZNF446
0.718
6
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.718
6
UniProt:Q96C00 ZBTB9
0.718
6
UniProt:O15409 FOXP2
0.718
6
UniProt:Q9UKT9 IKZF3
0.718
8
UniProt:O76015 KRT38
1
KRT38 [cytosol]
(R-HSA-6809615)
0.718
6
UniProt:Q6AI12 ANR40
0.718
6
UniProt:Q96MH2 HEXI2
0.718
6
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.718
6
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.71
5
UniProt:P85298-4 ARHGAP8
0.672
25
UniProt:P41212 ETV6
14
p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673912)
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673905)
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673893)
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673898)
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
(R-HSA-9697944)
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
(R-HSA-9703315)
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
(R-HSA-9703307)
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
(R-HSA-9703320)
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
(R-HSA-9703312)
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
(R-HSA-9703313)
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
(R-HSA-9703318)
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703305)
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703302)
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703308)
0.666
4
UniProt:Q93062 RBPMS
0.666
4
UniProt:Q9BWG4 SSBP4
0.666
4
UniProt:P35520 CBS
1
PXLP-K119-CBS [cytosol]
(R-HSA-1614563)
0.666
4
UniProt:Q9NYB9 ABI2
2
ABI2 [cytosol]
(R-HSA-1671647)
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
0.666
5
UniProt:Q15233 NONO
0.666
4
UniProt:Q9BT49 THAP7
0.666
5
UniProt:Q8NF64 ZMIZ2
0.666
4
UniProt:Q96AA8 JKIP2
0.666
4
UniProt:Q7Z5J4 RAI1
1
RAI1 [nucleoplasm]
(R-HSA-5656531)
0.666
4
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.666
4
UniProt:P41279 MAP3K8
3
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
0.66
8
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.646
4
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.645
10
UniProt:Q63932
3
phospho-p-S,T-MAP2K2 [cytosol]
(R-MMU-109848)
MAP2K2 [cytosol]
(R-MMU-59504)
phospho-p-S222,S226-MAP2K2 [cytosol]
(R-MMU-169292)
0.628
12
UniProt:Q13342 SP140
0.611
4
IntAct:EBI-10173330 386677
0.601
4
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.591
9
UniProt:Q15131 CDK10
0.591
5
UniProt:Q13950 RUNX2
0.591
7
UniProt:Q96A49 SYAP1
0.589
2
UniProt:Q9BR01 SULT4A1
1
SULT4A1 [cytosol]
(R-HSA-176668)
0.581
4
UniProt:P78563 ADARB1
1
ADARB1 [nucleoplasm]
(R-HSA-62915)
0.571
12
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.564
2
UniProt:P31938 Map2k1
5
phospho-p-S,218, S222,T292 MAP2K1 [cytosol]
(R-MMU-5674490)
phospho-p-T286,T292-MAP2K1 [cytosol]
(R-MMU-112374)
phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-MMU-112339)
Mek1 [cytosol]
(R-MMU-451658)
Phospho Mek1 [cytosol]
(R-MMU-451693)
0.558
4
UniProt:Q9H165-2 BCL11A
0.556
3
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.556
3
UniProt:Q9BTY2 FUCA2
4
FUCA2 [extracellular region]
(R-HSA-6806227)
FUCA2 [azurophil granule lumen]
(R-HSA-6798772)
p-FUCA2 [endoplasmic reticulum lumen]
(R-HSA-8957005)
FUCA2 [endoplasmic reticulum lumen]
(R-HSA-8956727)
0.556
3
UniProt:Q96IF1 AJUBA
3
AJUBA [cytosol]
(R-HSA-2564698)
p-S-AJUBA [cytosol]
(R-HSA-2574841)
AJUBA [nucleoplasm]
(R-HSA-5687935)
0.556
3
UniProt:Q9H0X6 RN208
0.556
3
UniProt:Q99708-2 RBBP8
0.556
3
UniProt:Q8N5C8 TAB3
3
TAB3 [plasma membrane]
(R-HSA-446879)
TAB3 [endosome membrane]
(R-HSA-450247)
TAB3 [cytosol]
(R-HSA-450264)
0.556
3
UniProt:Q8NC74 RB8NL
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:Q96MP8-2 KCTD7
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q03989 ARI5A
0.556
3
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q5TD97 FHL5
0.556
3
UniProt:Q9H0E9-2 BRD8
0.556
3
UniProt:Q13422 IKZF1
0.556
3
UniProt:Q12951-2 FOXI1
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q8NA61-2 CBY2
0.556
3
UniProt:O75553 DAB1
2
DAB1 [cytosol]
(R-HSA-8855236)
p-Y198,220,232-DAB1 [cytosol]
(R-HSA-8855227)
0.556
3
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.556
3
UniProt:Q4VCS5-2 AMOT
1
AMOT-2 [cytosol]
(R-HSA-9761473)
0.556
3
UniProt:Q14CS0 UBX2B
0.556
3
UniProt:Q9UKD1 GMEB2
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O00167-2 EYA2
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9UPG8 PLAL2
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:O76014 KRT37
1
KRT37 [cytosol]
(R-HSA-6809614)
0.556
3
UniProt:O15353 FOXN1
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:Q8NF64-3 ZMIZ2
0.556
3
UniProt:Q9H5H4 ZN768
0.556
5
UniProt:O94989 ARHGEF15
1
ARHGEF15 [cytosol]
(R-HSA-3550803)
0.556
3
UniProt:Q8NF64-2 ZMIZ2
0.556
3
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q63HR2 TENS2
0.556
3
UniProt:A1L4H1 SSC5D
1
SSC5D [extracellular region]
(R-HSA-8878615)
0.556
3
IntAct:EBI-22384398 CCSB ORF ID
0.556
3
UniProt:Q9NYB9-2 ABI2
0.556
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:Q53EZ4 CEP55
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
5
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q96KG9-4 SCYL1
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
IntAct:EBI-22343137 CCSB ORF ID
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.556
3
UniProt:Q16204 CCDC6
0.556
6
UniProt:Q494R4-2 DRC12
0.556
3
UniProt:P08151 GLI1
9
ub-GLI1 [cytosol]
(R-HSA-5635833)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary tip]
(R-HSA-5610360)
GLI1 [ciliary base]
(R-HSA-5610357)
0.556
3
UniProt:Q15233-2 NONO
0.556
3
UniProt:Q96M27 PRRC1
0.556
3
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.556
3
UniProt:Q6P9G9 ZN449
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q9HC98 NEK6
2
NEK6 [cytosol]
(R-HSA-2530596)
p-S206-NEK6 [cytosol]
(R-HSA-2984253)
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:P59797 SELV
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:A0A384NQ31 A0A384NQ31
0.556
3
UniProt:Q9HD90 NDF4
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:Q6ZMS7-2 Q6ZMS72
0.556
3
UniProt:O43281-2 EFS
0.556
3
UniProt:O15209 ZBT22
0.556
3
UniProt:Q8TF50 ZN526
0.556
3
UniProt:Q9NZQ3-3 NCKIPSD
0.556
3
UniProt:Q8N680 ZBTB2
0.556
3
UniProt:P40424 PBX1
1
PBX1 [nucleoplasm]
(R-HSA-453045)
0.556
3
UniProt:O75553-5 DAB1
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q8NFH5 NUP35
2
NUP35 [cytosol]
(R-HSA-9634171)
NUP35 [nuclear envelope]
(R-HSA-157748)
0.556
5
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:A2BDD9 A2BDD9
0.556
3
UniProt:P60371 KRTAP10-6
1
KRTAP10-6 [cytosol]
(R-HSA-6810247)
0.556
3
UniProt:P13349 MYF5
1
MYF5 [nucleoplasm]
(R-HSA-445158)
0.556
3
UniProt:P15407 FOSL1
1
FOSL1 [nucleoplasm]
(R-HSA-9620405)
0.556
3
UniProt:Q8NA61 CBY2
0.556
3
UniProt:O15156 ZBT7B
0.556
3
UniProt:Q99081-3 TCF12
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q9H7P9 PLEKHG2
1
PLEKHG2 [cytosol]
(R-HSA-195043)
0.556
3
UniProt:P55198 AF17
0.556
3
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.556
3
UniProt:Q8N9R8 SCAI
1
SCAI [nucleoplasm]
(R-HSA-5666012)
0.556
3
UniProt:Q92570 NR4A3
1
NR4A3 [nucleoplasm]
(R-HSA-8938004)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
5
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.544
2
UniProt:Q3UVX5
1
GRM5 [plasma membrane]
(R-MMU-420553)
0.544
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:P48426 PIP4K2A
2
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
PIP4K2A [cytosol]
(R-HSA-1604641)
0.527
2
UniProt:P04798 CYP1A1
1
CYP1A1 [endoplasmic reticulum membrane]
(R-HSA-52623)
0.527
2
UniProt:P31424-2 GRM5
0.524
3
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.508
5
UniProt:Q99728-1 BARD1
0.499
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text