OTUD5 deubiquitinates TRAF3

Stable Identifier
R-HSA-936381
Type
Reaction
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
Synonyms
Negative regulation of RIG-I/MDA5 signaling by DUBA
Locations in the PathwayBrowser
Summation

OTUD5 (Deubiquitinating enzyme A (DUBA)) is a negative regulator of type I interferon (IFN-) production. TRAF3, an E3 ubiquitin ligase that preferentially assembles lysine-63-linked polyubiquitin chains, is one of the targets of OTUD5. Expression of DUBA increases the cleavage of K63-linked ubiquitin chains from TRAF3, resulting in its dissociation from the downstream signaling complex that contains TANK-binding kinase 1 (TBK1) (Kayagaki et al. 2007), which leads to blockade of IRF3 and IRF7 phosphorylation.

Literature References
PubMed ID Title Journal Year
17991829 DUBA: a deubiquitinase that regulates type I interferon production Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of OTUD5 [cytosol]
Physical Entity
Activity