OTUD5 deubiquitinates TRAF3

Stable Identifier
R-HSA-936381
Type
Reaction
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
Synonyms
Negative regulation of RIG-I/MDA5 signaling by DUBA
Locations in the PathwayBrowser
Summation

OTUD5 (Deubiquitinating enzyme A (DUBA)) is a negative regulator of type I interferon (IFN-) production. TRAF3, an E3 ubiquitin ligase that preferentially assembles lysine-63-linked polyubiquitin chains, is one of the targets of OTUD5. Expression of DUBA increases the cleavage of K63-linked ubiquitin chains from TRAF3, resulting in its dissociation from the downstream signaling complex that contains TANK-binding kinase 1 (TBK1) (Kayagaki et al. 2007), which leads to blockade of IRF3 and IRF7 phosphorylation.

Literature References
PubMed ID Title Journal Year
17991829 DUBA: a deubiquitinase that regulates type I interferon production

Kayagaki, N, Phung, Q, Chan, S, Chaudhari, R, Quan, C, O'Rourke, KM, Eby, M, Pietras, E, Cheng, G, Bazan, JF, Zhang, Z, Arnott, D, Dixit, VM

Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of OTUD5 [cytosol]
Physical Entity
Activity
Authored
Reviewed