OTUD5 deubiquitinates TRAF3

Stable Identifier
R-HSA-936381
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
Synonyms
Negative regulation of RIG-I/MDA5 signaling by DUBA
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
OTUD5 (Deubiquitinating enzyme A (DUBA)) is a negative regulator of type I interferon (IFN-) production. TRAF3, an E3 ubiquitin ligase that preferentially assembles lysine-63-linked polyubiquitin chains, is one of the targets of OTUD5. Expression of DUBA increases the cleavage of K63-linked ubiquitin chains from TRAF3, resulting in its dissociation from the downstream signaling complex that contains TANK-binding kinase 1 (TBK1) (Kayagaki et al. 2007), which leads to blockade of IRF3 and IRF7 phosphorylation.
Literature References
PubMed ID Title Journal Year
17991829 DUBA: a deubiquitinase that regulates type I interferon production

Dixit, VM, Zhang, Z, Eby, M, Kayagaki, N, Quan, C, Arnott, D, Chaudhari, R, O'Rourke, KM, Cheng, G, Bazan, JF, Chan, S, Pietras, E, Phung, Q

Science 2007
Participants
Participates
Catalyst Activity

Lys63-specific deubiquitinase activity of OTUD5 [cytosol]

Authored
Reviewed
Created
Cite Us!