CYLD mediated deubiquitination of DDX58 (RIG-I)

Stable Identifier
R-HSA-936390
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of DDX58 (RIG-I) mediated antiviral signaling. CYLD associates with the CARD domain of DDX58 and removes K63-linked ubiquitin from the DDX58 CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.

Literature References
PubMed ID Title Journal Year
18467330 Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD

Zhang, M, Wu, X, Lee, AJ, Jin, W, Chang, M, Wright, A, Imaizumi, T, Sun, SC

J Biol Chem 2008
18636086 The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

Friedman, CS, O'Donnell, MA, Legarda-Addison, D, Ng, A, Cardenas, WB, Yount, JS, Moran, TM, Basler, CF, Komuro, A, Horvath, CM, Xavier, R, Ting, AT

EMBO Rep 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Lys63-specific deubiquitinase activity of CYLD [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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