Reactome | CYLD mediated deubiquitination of DDX58 (RIG-I)

CYLD mediated deubiquitination of DDX58 (RIG-I)

Stable Identifier

R-HSA-936390

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CYLD mediated deubiquitination of DDX58 (RIG-I)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of DDX58 (RIG-I) mediated antiviral signaling. CYLD associates with the CARD domain of DDX58 and removes K63-linked ubiquitin from the DDX58 CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.

Literature References

PubMed ID	Title	Journal	Year
18636086	The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response Friedman, CS, O'Donnell, MA, Legarda-Addison, D, Ng, A, Cardenas, WB, Yount, JS, Moran, TM, Basler, CF, Komuro, A, Horvath, CM, Xavier, R, Ting, AT	EMBO Rep	2008
18467330	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD Zhang, M, Wu, X, Lee, AJ, Jin, W, Chang, M, Wright, A, Imaizumi, T, Sun, SC	J Biol Chem	2008