Reactome | CYLD mediated deubiquitination of DDX58 (RIG-I)

CYLD mediated deubiquitination of DDX58 (RIG-I)

Stable Identifier

R-HSA-936390

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CYLD mediated deubiquitination of DDX58 (RIG-I)

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CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of DDX58 (RIG-I) mediated antiviral signaling. CYLD associates with the CARD domain of DDX58 and removes K63-linked ubiquitin from the DDX58 CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135.

Literature References

PubMed ID	Title	Journal	Year
18636086	The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response Horvath, CM, Moran, TM, Yount, JS, Ng, A, Legarda-Addison, D, Xavier, R, Komuro, A, Ting, AT, O'Donnell, MA, Basler, CF, Cardenas, WB, Friedman, CS	EMBO Rep	2008
18467330	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD Wright, A, Lee, AJ, Zhang, M, Sun, SC, Jin, W, Imaizumi, T, Chang, M, Wu, X	J Biol Chem	2008