Negative regulators of DDX58/IFIH1 signaling

Stable Identifier
R-HSA-936440
Type
Pathway
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Synonyms
Negative regulators of RIG-I/MDA5 signaling
Locations in the PathwayBrowser
Summation

As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I and MDA5.

Literature References
PubMed ID Title Journal Year
18703349 Negative regulation of cytoplasmic RNA-mediated antiviral signaling

Komuro, A, Bamming, D, Horvath, CM

Cytokine 2008
18549796 Regulation of mitochondrial antiviral signaling pathways

Moore, CB, Ting, JP

Immunity 2008
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created