Reactome | ISG15 [cytosol]

ISG15 [cytosol]

Stable Identifier

R-HSA-936552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon-induced 17 kDa protein component recommendedName: Ubiquitin cross-reactive protein, UCRP_HUMAN

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External Reference Information

External Reference

UniProt:P05161 ISG15

Gene Names

ISG15, G1P2, UCRP

Chain

initiator methionine:1, chain:2-157, propeptide:158-165

Reference Genes

BioGPS Gene:9636 ISG15

COSMIC (genes):ISG15 ISG15

CTD Gene:9636 ISG15

dbSNP Gene:9636 ISG15

ENSEMBL:ENSG00000187608 ISG15

HGNC:4053 ISG15

KEGG Gene (Homo sapiens):9636 ISG15

Monarch:9636 ISG15

NCBI Gene:9636 ISG15

OMIM:147571 ISG15

UCSC:P05161 ISG15

Reference Transcript

RefSeq:NM_005101.3 ISG15

Other Identifiers

0004590398

1107_s_at

11716895_s_at

16657594

205483_s_at

38432_at

4053544

4053545

4053546

4053547

4053548

4053549

7896817

9636

A_23_P819

GE62795

GO:0002376

GO:0003674

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006259

GO:0006464

GO:0006950

GO:0007165

GO:0007229

GO:0008150

GO:0009056

GO:0009058

GO:0009617

GO:0015935

GO:0016032

GO:0019899

GO:0019941

GO:0019985

GO:0022627

GO:0030154

GO:0030501

GO:0031386

GO:0031397

GO:0031625

GO:0032020

GO:0032480

GO:0032609

GO:0032613

GO:0032649

GO:0032991

GO:0034340

GO:0034641

GO:0042592

GO:0042742

GO:0043226

GO:0044403

GO:0045071

GO:0045087

GO:0045648

GO:0048856

GO:0051607

GO:0060337

ILMN_1813289

ILMN_2054019

M13755_at

PH_hs_0028539

TC01000023.hg

g4826773_3p_a_at

Participant Of

hasComponent

input

output

Expression of IFN-induced genes

This entity regulates

Negatively

Monoubiquitination of N-myristoyl GAG (P12493) protein

Other forms of this molecule

ISG15 [nucleoplasm]

K168-PCNA-G157-ISG15 [nucleoplasm]

K164-PCNA-G157-ISG15 [nucleoplasm]

Inferred To

Ubi-p5E5 [cytosol] (Drosophila melanogaster)

ubb [cytosol] (Danio rerio)

ubqB [cytosol] (Dictyostelium discoideum)

uba52 [cytosol] (Danio rerio)

uba52 [cytosol] (Xenopus tropicalis)

Ghost homologue of ISG15 [cytosol] (Caenorhabditis elegans)

Ghost homologue of ISG15 [cytosol] (Gallus gallus)

Isg15 [cytosol] (Mus musculus)

Isg15 [cytosol] (Rattus norvegicus)

RpL40 [cytosol] (Drosophila melanogaster)

ubqO [cytosol] (Dictyostelium discoideum)

ISG15 [cytosol] (Bos taurus)

ISG15 [cytosol] (Canis familiaris)

ISG15 [cytosol] (Danio rerio)

ISG15 [cytosol] (Plasmodium falciparum)

ISG15 [cytosol] (Sus scrofa)

Homologues of ISG15 [cytosol] (Danio rerio)

Homologues of ISG15 [cytosol] (Dictyostelium discoideum)

Homologues of ISG15 [cytosol] (Drosophila melanogaster)

ubqC [cytosol] (Dictyostelium discoideum)

RpS27A [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_005092.1

Target Pathogen

5b354852be737e166372ee3b

OpenTargets

ENSG00000187608

GeneCards

P05161

HPA

ENSG00000187608-ISG15

Ensembl

ENSG00000187608, ENST00000649529, ENSP00000496832

PRO

P05161

Orphanet

21556

PDB

5TL6, 6FFA, 6BI8, 5W8U, 5W8T, 3R66, 3PHX, 6XA9, 2HJ8, 3SDL, 3RT3, 1Z2M, 3PSE

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UMW8 USP18	1	USP18 [cytosol] (R-HSA-912325)	0.873	9
UniProt:P41226 UBA7	2	UBA7 [cytosol] (R-HSA-936550) UBA7 [nucleoplasm] (R-HSA-5653762)	0.836	10
UniProt:Q6TQR6 L			0.743	5
UniProt:P0C6U8-PRO_0000338257			0.719	5
UniProt:P03502 NS1			0.65	4
UniProt:P0DTD1-PRO_0000449621 REP			0.618	4
UniProt:K0BWD0 K0BWD0			0.618	4
UniProt:P03495 NS1			0.602	4
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.591	4
UniProt:O75688 PPM1B	1	PPM1B [cytosol] (R-HSA-1169375)	0.558	2
UniProt:O60260-5 PRKN			0.556	3