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ISG15 [cytosol]
Stable Identifier
R-HSA-936552
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interferon-induced 17 kDa protein component recommendedName: Ubiquitin cross-reactive protein, UCRP_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated 4EHP:mRNA [cytosol] (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of E2 conjugating enzymes (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated E2 conjugating enzymes [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of IRF3 (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of host protein filamin B (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated Filamin B [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of host proteins (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated host proteins [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated PP2CB [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of protein translation regulator 4EHP (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated 4EHP [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylation of viral protein NS1 (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:NEDD4 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Homo sapiens)
ISGylated host proteins [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)
ISG15:UBA7 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:UBCH8 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus (Homo sapiens)
ISGylated NS1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
ISGylation of DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
viral dsRNA binds DDX58 (Homo sapiens)
ISG15:DDX58 conjugate [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)
ISG15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05161 ISG15
Gene Names
ISG15, G1P2, UCRP
Chain
initiator methionine:1, chain:2-157, propeptide:158-165
Reference Genes
BioGPS Gene:9636 ISG15
COSMIC (genes):ISG15 ISG15
CTD Gene:9636 ISG15
dbSNP Gene:9636 ISG15
ENSEMBL:ENSG00000187608 ISG15
HGNC:4053 ISG15
KEGG Gene (Homo sapiens):9636 ISG15
Monarch:9636 ISG15
NCBI Gene:9636 ISG15
OMIM:147571 ISG15
UCSC:P05161 ISG15
Reference Transcript
RefSeq:NM_005101.3 ISG15
Other Identifiers
0004590398
1107_s_at
11716895_s_at
16657594
205483_s_at
38432_at
4053544
4053545
4053546
4053547
4053548
4053549
7896817
9636
A_23_P819
GE62795
GO:0002376
GO:0003674
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005840
GO:0006259
GO:0006464
GO:0006950
GO:0007165
GO:0007229
GO:0008150
GO:0009056
GO:0009058
GO:0009617
GO:0015935
GO:0016032
GO:0019899
GO:0019941
GO:0019985
GO:0022627
GO:0030154
GO:0030501
GO:0031386
GO:0031397
GO:0031625
GO:0032020
GO:0032480
GO:0032609
GO:0032613
GO:0032649
GO:0032991
GO:0034340
GO:0034641
GO:0042592
GO:0042742
GO:0043226
GO:0044403
GO:0045071
GO:0045087
GO:0045648
GO:0048856
GO:0051607
GO:0060337
ILMN_1813289
ILMN_2054019
M13755_at
PH_hs_0028539
TC01000023.hg
g4826773_3p_a_at
Participant Of
hasComponent
ISG15:NEDD4 [cytosol]
ISG15:UBA7 [cytosol]
ISG15:UBCH8 [cytosol]
ISG15:UBEIL/UbcH8:CEB1 [cytosol]
ISGylated E2 conjugating enzymes [cytosol]
ISGylated Filamin B [cytosol]
ISGylated host proteins [cytosol]
ISGylated IRF3 [cytosol]
ISGylated NS1 [cytosol]
ISGylated PP2CB [cytosol]
input
Activation of ISG15 by UBA7 E1 ligase
Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
output
Expression of IFN-induced genes
This entity regulates
Negatively
Monoubiquitination of N-myristoyl GAG (P12493) protein
Other forms of this molecule
ISG15 [nucleoplasm]
K168-PCNA-G157-ISG15 [nucleoplasm]
K164-PCNA-G157-ISG15 [nucleoplasm]
Inferred To
Ubi-p5E5 [cytosol] (Drosophila melanogaster)
ubb [cytosol] (Danio rerio)
ubqB [cytosol] (Dictyostelium discoideum)
uba52 [cytosol] (Danio rerio)
uba52 [cytosol] (Xenopus tropicalis)
Ghost homologue of ISG15 [cytosol] (Caenorhabditis elegans)
Ghost homologue of ISG15 [cytosol] (Gallus gallus)
Isg15 [cytosol] (Mus musculus)
Isg15 [cytosol] (Rattus norvegicus)
RpL40 [cytosol] (Drosophila melanogaster)
ubqO [cytosol] (Dictyostelium discoideum)
ISG15 [cytosol] (Bos taurus)
ISG15 [cytosol] (Canis familiaris)
ISG15 [cytosol] (Danio rerio)
ISG15 [cytosol] (Plasmodium falciparum)
ISG15 [cytosol] (Sus scrofa)
Homologues of ISG15 [cytosol] (Danio rerio)
Homologues of ISG15 [cytosol] (Dictyostelium discoideum)
Homologues of ISG15 [cytosol] (Drosophila melanogaster)
ubqC [cytosol] (Dictyostelium discoideum)
RpS27A [cytosol] (Drosophila melanogaster)
Cross References
RefSeq
NP_005092.1
Target Pathogen
5b354852be737e166372ee3b
OpenTargets
ENSG00000187608
GeneCards
P05161
HPA
ENSG00000187608-ISG15
Ensembl
ENSG00000187608
,
ENST00000649529
,
ENSP00000496832
PRO
P05161
Orphanet
21556
PDB
5TL6
,
6FFA
,
6BI8
,
5W8U
,
5W8T
,
3R66
,
3PHX
,
6XA9
,
2HJ8
,
3SDL
,
3RT3
,
1Z2M
,
3PSE
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMW8 USP18
1
USP18 [cytosol]
(R-HSA-912325)
0.873
9
UniProt:P41226 UBA7
2
UBA7 [cytosol]
(R-HSA-936550)
UBA7 [nucleoplasm]
(R-HSA-5653762)
0.836
10
UniProt:Q6TQR6 L
0.743
5
UniProt:P0C6U8-PRO_0000338257
0.719
5
UniProt:P03502 NS1
0.65
4
UniProt:P0DTD1-PRO_0000449621 REP
0.618
4
UniProt:K0BWD0 K0BWD0
0.618
4
UniProt:P03495 NS1
0.602
4
UniProt:O75369 FLNB
1
FLNB [cytosol]
(R-HSA-354163)
0.591
4
UniProt:O75688 PPM1B
1
PPM1B [cytosol]
(R-HSA-1169375)
0.558
2
UniProt:O60260-5 PRKN
0.556
3
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