K48polyUb-TRAF3 [cytosol]

Stable Identifier
R-HSA-936556
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48-polyubiquitin TRAF3
Icon
K48polyUb-TRAF3 [cytosol] icon
K48polyUb-TRAF3 [cytosol] icon
Locations in the PathwayBrowser for interactor UniProt:Q8TDR0 TRAF3IP1
Expand all
Literature References
PubMed ID Title Journal Year
19893624 The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

Nakhaei, P, Mesplede, T, Solis, M, Sun, Q, Zhao, T, Yang, L, Chuang, TH, Ware, CF, Lin, R, Hiscott, J

PLoS Pathog 2009
External Reference Information
External Reference
UniProt:Q13114 TRAF3
Gene Names
TRAF3, CAP1, CRAF1
Chain
chain:1-568
Reference Genes
BioGPS Gene:7187 TRAF3
COSMIC (genes):TRAF3 TRAF3
CTD Gene:7187 TRAF3
dbSNP Gene:7187 TRAF3
ENSEMBL:ENSG00000131323 TRAF3
HGNC:12033 TRAF3
KEGG Gene (Homo sapiens):7187 TRAF3
Monarch:7187 TRAF3
NCBI Gene:7187 TRAF3
OMIM:601896 TRAF3
UCSC:Q13114 TRAF3
Reference Transcript
Other Identifiers
0000940739
11742091_a_at
11743501_a_at
11759502_at
16789080
208315_3p_x_at
208315_x_at
221571_at
3553338
3553346
3553358
3553359
3553363
3553364
3553367
3553368
3553370
3553374
3553382
3553383
3553384
3553386
3553388
37057_s_at
43952_at
7187
7977018
A_23_P37068
A_32_P89837
GE59008
GO:0001817
GO:0002224
GO:0002376
GO:0003674
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006915
GO:0006950
GO:0007165
GO:0008063
GO:0008150
GO:0008219
GO:0008270
GO:0009058
GO:0009898
GO:0016579
GO:0016740
GO:0019899
GO:0019901
GO:0019903
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032648
GO:0032991
GO:0033209
GO:0034641
GO:0035631
GO:0035666
GO:0042802
GO:0042981
GO:0043122
GO:0043167
GO:0043226
GO:0045087
GO:0046330
GO:0046872
GO:0050688
GO:0070534
Hs.297660.1.S2_3p_at
ILMN_1793154
ILMN_2383774
PH_hs_0015383
PH_hs_0038599
TC14000786.hg
U15637_s_at
g4507678_3p_a_at
g4507678_3p_at
g4507678_3p_x_at
Participant Of
output
Other forms of this molecule
TRAF3 R118W [cytosol]
K48polyUb-TRAF3 [cytosol]
TRAF3 [cytosol]
K63polyUb-TRAF3 [cytosol]
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
OpenTargets
IntEnz
HPA
GeneCards
Ensembl
PRO
Orphanet
PDB
Interactors (40)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q99558 MAP3K14  5 0.85 8
 UniProt:Q92844 TANK  2 0.77 6
 UniProt:Q13546 RIPK1  14 0.703 5
 UniProt:O00463 TRAF5      0.675 4
 UniProt:O95721 SNAP29  3 0.666 4
 UniProt:Q8TDR0 TRAF3IP1  2 0.639 8
 UniProt:O43353 RIPK2  2 0.633 5
 UniProt:P36941 LTBR  1 0.564 2
 UniProt:Q9HAV5 EDA2R  1 0.564 2
 UniProt:Q5T681 CJ062      0.556 3
 UniProt:Q52MB2 CC184      0.556 3
 UniProt:Q8IYE1 CCD13      0.556 3
 UniProt:Q6ZSB9 ZBT49      0.556 3
 UniProt:Q8NAM6 ZSCA4      0.556 3
 UniProt:Q7KZS0 Q7KZS0      0.556 3
 UniProt:Q8N9N2-2 ASCC1      0.556 3
 UniProt:Q9UKD1 GMEB2      0.556 3
 UniProt:Q16543 CDC37  1 0.556 3
 UniProt:Q13114 TRAF3  5 0.556 5
 UniProt:Q86UB2 BIVM      0.556 6
 UniProt:Q8TBB1 LNX1  1 0.556 3
 UniProt:Q0D2K3 RIPP1      0.556 3
 UniProt:P28062-2 PSMB8      0.556 3
 IntAct:EBI-22505066 CCSB ORF ID      0.556 3
 UniProt:P54725 RAD23A  1 0.556 3
 UniProt:Q17RL8 Q17RL8      0.556 3
 UniProt:P78317 RNF4  2 0.556 3
 UniProt:Q96HA1-2 POM121      0.556 3
 UniProt:Q96HA8 NTAQ1      0.556 3
 UniProt:Q96PC2 IP6K3  1 0.556 5
 UniProt:Q9Y547 HSPB11  2 0.556 3
 UniProt:O75928-2 PIAS2  1 0.556 3
 UniProt:Q15628 TRADD  1 0.547 2
 UniProt:Q13490 BIRC2  5 0.527 3
 UniProt:P61964 WDR5  1 0.524 2
 UniProt:P25942 CD40      0.508 3
 UniProt:Q9Y692 GMEB1      0.508 2
 UniProt:Q9QYP6 AZI2      0.499 2
 UniProt:P15314  1 0.499 2
 UniProt:A2APF7 A2APF7      0.499 2
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