ISGylation of DDX58

Stable Identifier
R-HSA-936563
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
ISGylation of RIG-I
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ISG15 is an ubiquitin (Ub)-like protein which is conjugated to intracellular proteins via an isopeptide bond. Similar to ubiquitination, the conjugation of ISG15 (ISGylation) requires a three-step process, involving an E1 activating enzyme (UBE1L), an E2 conjugating enzyme (UbcM8/H8), and HERC5/Ceb1 an IFN-inducible ISG15-specific E3 ligase. ISG15 conjugation may play an important regulatory role in IFN-mediated antiviral responses. IFN induces ISG15 conjugation to DDX58 negatively regulating DDX58-mediated antiviral signaling. ISGylated DDX58 becomes subject to an irreversible biochemical process, such as proteolysis or proteasomeal degradation.

Literature References
PubMed ID Title Journal Year
18057259 Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation

Kim, MJ, Hwang, SY, Imaizumi, T, Yoo, JY

J Virol 2008
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