Reactome | TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Stable Identifier

R-HSA-936976

Type

Complex

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

activated TLR4:TRIF:TRAF6

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15814722	Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif Kaiser, WJ, Offermann, MK	J Immunol	2005
16115877	Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation Cusson-Hermance, N, Khurana, S, Lee, TH, Fitzgerald, KA, Kelliher, MA	J Biol Chem	2005
14982987	Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta Jiang, Z, Mak, TW, Sen, G, Li, X	Proc. Natl. Acad. Sci. U.S.A.	2004
16306937	Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 Häcker, H, Redecke, V, Blagoev, B, Kratchmarova, I, Hsu, LC, Wang, GG, Kamps, MP, Raz, E, Wagner, H, Häcker, G, Mann, M, Karin, M	Nature	2006
14530355	Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling Sato, S, Sugiyama, M, Yamamoto, M, Watanabe, Y, Kawai, T, Takeda, K, Akira, S	J. Immunol.	2003

Participants

components

Participant Of

output

Activated TLR4:TICAM1 recruits TRAF6

input

Auto ubiquitination of TRAF6 bound to the activated TLR4 complex

Inferred To

TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)

TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Mus musculus)

TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)

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