Reactome | p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

Stable Identifier

R-HSA-937011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-6T-IRAK1, p-3S,3T-IRAK1, Interleukin-1 receptor-associated kinase 1(phosphorylated), IRAK1_HUMAN, IRAK1

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General

This is the hyperphosphorylated, active form of IRAK1. The unknown coordinate phosphorylation events are to symbolize the multiple phosphorylations that likely take place in the ProST domain (aa10-211).

External Reference Information

External Reference

UniProt:P51617 IRAK1

Gene Names

IRAK1, IRAK

Chain

chain:1-712

Reference Genes

BioGPS Gene:3654 IRAK1

COSMIC (genes):IRAK1 IRAK1

CTD Gene:3654 IRAK1

dbSNP Gene:3654 IRAK1

ENSEMBL:ENSG00000184216 IRAK1

HGNC:6112 IRAK1

KEGG Gene (Homo sapiens):3654 IRAK1

Monarch:3654 IRAK1

NCBI Gene:3654 IRAK1

OMIM:300283 IRAK1

UCSC:P51617 IRAK1

Reference Transcript

Other Identifiers

0002230021

1100_at

11734006_a_at

1555784_s_at

17115428

201587_s_at

3654

4027010

4027011

4027012

4027013

4027014

4027015

4027016

4027017

4027018

4027021

4027022

4027023

4027024

4027027

4027028

4027029

4027031

4027033

4027034

4027037

4027038

4027040

4027041

4027043

4027045

4027046

4027048

4027050

4027051

4027052

4027053

8175977

A_23_P73780

A_33_P3286616

GE62370

GO:0000166

GO:0000187

GO:0001959

GO:0002224

GO:0002376

GO:0002755

GO:0003674

GO:0004672

GO:0004674

GO:0004704

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005811

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006950

GO:0007155

GO:0007165

GO:0007250

GO:0007254

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0010008

GO:0016020

GO:0016032

GO:0016301

GO:0016310

GO:0016740

GO:0019221

GO:0030234

GO:0031072

GO:0031410

GO:0031663

GO:0032088

GO:0032481

GO:0032496

GO:0032991

GO:0034134

GO:0034142

GO:0034162

GO:0034605

GO:0034641

GO:0035556

GO:0042802

GO:0042803

GO:0043066

GO:0043123

GO:0043167

GO:0043226

GO:0043406

GO:0044403

GO:0045087

GO:0046777

GO:0046982

GO:0048661

GO:0051092

GO:0060337

GO:0070423

GO:0070498

GO:0070555

GO:0071222

GO:0071456

GO:1901224

GO:1904996

Hs2.182018.3.S1_3p_s_at

ILMN_1738397

ILMN_2379130

ILMN_3310740

L76191_at

PH_hs_0010754

TC0X001524.hg

g4755143_3p_s_at

Participant Of

hasComponent

hasMember

hp-IRAK1/p-IRAK2 [plasma membrane]

Other forms of this molecule

K63polyUb-hp-IRAK1 [endosome membrane]

p-T209-IRAK1 [endosome membrane]

p-T209,T387-IRAK1 [endosome membrane]

IRAK1 [endosome membrane]

p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]

p-S,T-IRAK1 [cytosol]

p-S376,T387-IRAK1 [cytosol]

K63polyUb-hp-IRAK1 [cytosol]

IRAK1 [plasma membrane]

p-T209-IRAK1 [plasma membrane]

p-T209,T387-IRAK1 [plasma membrane]

IRAK1 [cytosol]

p-2S,S376,T,T209,T387-IRAK1 [cytosol]

Inferred To

phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (Dictyostelium discoideum)

phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (Sus scrofa)

phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (Xenopus tropicalis)

phospho-Irak1 [plasma membrane] (Mus musculus)

phospho-Irak1 [plasma membrane] (Rattus norvegicus)

phospho-IRAK1 [plasma membrane] (Canis familiaris)

phospho-irak1 [plasma membrane] (Danio rerio)

phospho-pll [plasma membrane] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 387

Coordinate

387

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 376

Coordinate

376

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 209

Coordinate

209

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001020414.1, NP_001020413.1, NP_001560.2

ZINC - World Drugs

IRAK1_HUMAN

OpenTargets

ENSG00000184216

ZINC - FDA approved

IRAK1_HUMAN

ZINC - Substances

IRAK1_HUMAN

ZINC target

P51617

ZINC - Biogenic

IRAK1_HUMAN

PRO

P51617

PDB

6BFN

ZINC - Investigational

IRAK1_HUMAN

IntEnz

2.7.11.1

GeneCards

P51617

HPA

ENSG00000184216-IRAK1

Ensembl

ENST00000393687, ENSG00000184216, ENSP00000358997, ENSP00000377291, ENST00000369974, ENSP00000358991, ENST00000369980

ZINC - Predictions - Purchasable

IRAK1_HUMAN

Orphanet

22427

HMDB Protein

HMDBP08733

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.743	4
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.734	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.702	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.645	10
UniProt:Q99836 MYD88	9	MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329) MYD88 [cytosol] (R-HSA-193946) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612)	0.641	3
UniProt:Q8N2H9-2 PELI3			0.589	2
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.564	3
UniProt:O43187 IRAK2	6	p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [endosome membrane] (R-HSA-975116) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.564	3
UniProt:Q9NWZ3 IRAK4	9	IRAK4 Q293TER [cytosol] (R-HSA-5602426) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 E402TER [cytosol] (R-HSA-5602517) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [cytosol] (R-HSA-166081)	0.547	2
UniProt:Q5D1E7 ZC12A			0.544	3
UniProt:Q92985 IRF7	5	IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.499	2
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.499	2
UniProt:Q86WV6 STING1	5	TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940)	0.499	2
UniProt:Q8VCW4	2	Unc93b1 [Golgi membrane] (R-MMU-1679064) Unc93b1 [endoplasmic reticulum membrane] (R-MMU-1678930)	0.499	2
UniProt:Q15306 IRF4	1	IRF4 [cytosol] (R-HSA-1015679)	0.499	2