Reactome: A Curated Pathway Database

IKK complex recruitment mediated by RIP1

Stable Identifier
R-HSA-937041
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways [Ea et al. 2006]. Poly(I-C) treatment stimulated the recruitment of RIP1, TRAF6, and TAK1 to the TLR3 receptor complex in human embryonic kidney HEK293 transfected with FLAG-tagged TLR3 [Cusson-Hermance et al. 2005]. RIP1 was shown to be dispensable for TRIF-dependent activation of IRF3, which occurs in a TRIF/TBK1/IKKi-dependent manner [Cusson-Hermance et al. 2005, Sato et al. 2003]

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database