TRIF(TICAM1)-mediated TLR4 signaling

Stable Identifier
R-HSA-937061
Type
Pathway
Species
Homo sapiens
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TRIF(TICAM1) was shown to induce IRF3/7 and NFkappaB activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680).

The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex.

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Yamamoto, M, Sato, S, Hemmi, H, Hoshino, K, Kaisho, T, Sanjo, H, Takeuchi, O, Sugiyama, M, Okabe, M, Takeda, K

Science 2003
15814722 Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

Kaiser, WJ, Offermann, MK

J Immunol 2005
14739303 Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways

Han, KJ, Su, X, Xu, LG, Bin, LH, Zhang, J, Shu, HB

J. Biol. Chem. 2004
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Orthologous Events
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