TRIF(TICAM1) was shown to induce IRF3/7 and NFkappaB activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists of an N-terminal region (1-234), a TIR domain (235-500), and a C-terminal region (501-680).
The N-terminal region of TRIF harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases. The C-terminal region of TRIF can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex.
Offermann, MK, Kaiser, WJ
Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H
Zhang, J, Shu, HB, Han, KJ, Bin, LH, Su, X, Xu, LG
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