ATP4A/12A:ATP4B exchanges K+ for H+

Stable Identifier
R-HSA-937311
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions
Locations in the PathwayBrowser
Summation

The potassium-transporting ATPase heterodimer (ATP4A/12A:ATP4B) catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is composed of alpha and beta chains. Two human genes encode the catalytic alpha subunit, ATP4A and ATP12A (Maeda et al, 1990; Grishin et al, 1994). ATP4A is responsible for acid production in the stomach. ATP12A is responsible for potassium absorption in various tissues. One human gene encodes the beta subunit, ATP4B (Ma et al, 1991).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydrogen:potassium-exchanging ATPase activity of ATP4A/12A:ATP4B [plasma membrane]
Physical Entity
Activity
Orthologous Events