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NLRC5 [cytosol]
Stable Identifier
R-HSA-937324
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein NLRC5, NLRC5_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Regulation of NF-kappa B signaling (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
USP14 deubiquitinates NLRC5 (Homo sapiens)
NLRC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86WI3 NLRC5
Gene Names
NLRC5, NOD27, NOD4
Chain
chain:1-1866
Reference Genes
BioGPS Gene:84166 NLRC5
COSMIC (genes):NLRC5 NLRC5
CTD Gene:84166 NLRC5
dbSNP Gene:84166 NLRC5
ENSEMBL:ENSG00000140853 NLRC5
HGNC:29933 NLRC5
KEGG:hsa:84166 NLRC5
Monarch:84166 NLRC5
NCBI Gene:84166 NLRC5
OMIM:613537 NLRC5
UCSC:Q86WI3 NLRC5
Reference Transcript
RefSeq:XM_006721297.2 NLRC5
RefSeq:XM_005256197.2 NLRC5
RefSeq:XM_005256194.3 NLRC5
RefSeq:NM_032206.4 NLRC5
RefSeq:NM_001330552.1 NLRC5
RefSeq:XM_005256193.2 NLRC5
RefSeq:XM_011523373.2 NLRC5
Other Identifiers
11729523_a_at
11755758_s_at
16819355
226474_PM_at
226474_at
3662445
3662446
3662447
3662448
3662451
3662453
3662454
3662457
3662458
3662459
3662460
3662461
3662462
3662463
3662464
3662465
3662466
3662467
3662468
3662469
3662470
3662471
3662472
3662474
3662476
3662477
3662479
3662480
3662481
3662482
3662483
3662484
3662486
3662488
3662489
3662490
3662491
3662492
3662493
3662494
3662495
3662496
3662497
3662498
3662499
3662500
3662501
3662502
3662503
3662504
3662505
3662506
3662509
3662510
3662511
3662512
3662513
3662514
3662515
3662516
3662517
3662518
3662520
3662521
3662522
3662523
3662524
3662525
3662526
3662527
3662528
3662529
3662530
3662531
3662532
3662533
3662534
3662535
3662536
3662537
3662538
3662539
3662540
3662541
3662543
48099_at
66966_at
69683_at
7995926
84166
A_32_P416583
GE83335
GO:0000978
GO:0002376
GO:0003677
GO:0005096
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0009617
GO:0032088
GO:0035556
GO:0043226
GO:0043549
GO:0045087
GO:0045345
GO:0045944
GO:0051607
GO:0060335
GO:0060339
GO:0060340
GO:0098542
GO:0098772
HMNXSV003019860
HMNXSV003044372
HMNXSV003050308
Hs.10888.0.S1_3p_at
ILMN_1716704
PH_hs_0024279
TC16000482.hg
Participates
as an input of
NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)
NLRC5 binds IKBKB and CHUK (Homo sapiens)
as a component of
viral dsRNA:IFIH1, 2xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATP:NLRC5 [cytosol] (Homo sapiens)
CHUK:IKBKB:NLRC5 [endoplasmic reticulum membrane] (Homo sapiens)
as an output of
USP14 deubiquitinates NLRC5 (Homo sapiens)
Other forms of this molecule
K63polyUb-NLRC5 [cytosol]
Inferred To
NLRC5 [cytosol]
(Bos taurus)
NLRC5 [cytosol]
(Canis familiaris)
NLRC5 [cytosol]
(Dictyostelium discoideum)
NLRC5 [cytosol]
(Gallus gallus)
NLRC5 [cytosol]
(Mus musculus)
NLRC5 [cytosol]
(Sus scrofa)
Nlrc5 [cytosol]
(Rattus norvegicus)
Homologues of NLRC5 [cytosol]
(Dictyostelium discoideum)
nlrc5 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_006721360.1
,
XP_005256250.1
,
NP_115582.4
,
XP_005256251.1
,
NP_001317481.1
,
XP_011521675.1
,
XP_005256254.1
Guide to Pharmacology - Targets
1765
ENSEMBL
ENST00000688547
,
ENST00000262510
,
ENSP00000262510
,
ENSP00000509992
,
ENST00000539881
,
ENST00000539144
,
ENSP00000441679
,
ENSP00000441727
OpenTargets
ENSG00000140853
HPA
ENSG00000140853-NLRC5
PRO
Q86WI3
Pharos - Targets
Q86WI3
GlyGen
Q86WI3
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.524
2
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.524
3
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