TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination

Stable Identifier
R-HSA-937337
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TAX1BP1 functions as an adaptor molecule for A20 to terminate antiviral signaling. TAX1BP1 and A20 blocked antiviral signaling by disrupting K63-linked polyubiquitination of TBK1-IKKi.

Literature References
PubMed ID Title Journal Year
20304918 TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases J Biol Chem 2010
Participants
Participant Of
Orthologous Events