NLRC5 interacts with DDX58/IFIH1

Stable Identifier
R-HSA-937343
Type
Reaction
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol
Synonyms
NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding
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NLRC5 interacts with DDX58/IFIH1
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NLRC5 competes with IPS-1 for binding to the CARD domain of RIG-I/MDA5. NLRC5 specifically recognize the CARD domains of RIG-I/MDA5 when the CARD domains become accessible after viral infection, leading to dampened activation of IRF3.

Literature References
PubMed ID Title Journal Year
20434986 NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

Cui, J, Zhu, L, Xia, X, Wang, HY, Legras, X, Hong, J, Ji, J, Shen, P, Zheng, S, Chen, ZJ, Wang, RF

Cell 2010
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-26)