Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.
Stork, PJ, Dillon, TJ
Lafuente, E, Boussiotis, VA
Crittenden, JR, Bergmeier, W, Zhang, Y, Piffath, CL, Liang, Y, Wagner, DD, Housman, DE, Graybiel, AM
Lafuente, EM, van Puijenbroek, AA, Krause, M, Carman, CV, Freeman, GJ, Berezovskaya, A, Constantine, E, Springer, TA, Gertler, FB, Boussiotis, VA
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