Reactome | Activation of Rap1 by membrane-associated GEFs

Activation of Rap1 by membrane-associated GEFs

Stable Identifier

R-HSA-939265

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Activation of Rap1 by membrane-associated GEFs

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Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.

Literature References

PubMed ID	Title	Journal	Year
16076873	Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions Stork, PJ, Dillon, TJ	Blood	2005
16757337	Rap1 regulation of RIAM and cell adhesion Lafuente, E, Boussiotis, VA	Methods Enzymol	2006
15334074	CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation Crittenden, JR, Bergmeier, W, Zhang, Y, Piffath, CL, Liang, Y, Wagner, DD, Housman, DE, Graybiel, AM	Nat Med	2004
15469846	RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Lafuente, EM, van Puijenbroek, AA, Krause, M, Carman, CV, Freeman, GJ, Berezovskaya, A, Constantine, E, Springer, TA, Gertler, FB, Boussiotis, VA	Dev Cell	2004