Reactome | RGS2 [plasma membrane]

RGS2 [plasma membrane]

Stable Identifier

R-HSA-939787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Regulator of G-protein signaling 2, RGS2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P41220 RGS2

Gene Names

RGS2, G0S8, GIG31

Chain

chain:1-211

Reference Genes

BioGPS Gene:5997 RGS2

COSMIC (genes):RGS2 RGS2

CTD Gene:5997 RGS2

dbSNP Gene:5997 RGS2

ENSEMBL:ENSG00000116741 RGS2

HGNC:9998 RGS2

KEGG:hsa:5997 RGS2

Monarch:5997 RGS2

NCBI Gene:5997 RGS2

OMIM:600861 RGS2

UCSC:P41220 RGS2

Reference Transcript

RefSeq:NM_002923.3 RGS2

Other Identifiers

11715757_a_at

16675323

202388_PM_at

202388_at

2372867

2372868

2372869

2372870

2372872

2372873

2372874

2372875

2372876

2372877

2372878

2372879

2372880

2372881

37701_at

5997

7908409

A_14_P131833

A_23_P114947

GE61353

GE79018

GO:0001965

GO:0001975

GO:0003012

GO:0003824

GO:0003924

GO:0005096

GO:0005515

GO:0005516

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006417

GO:0007186

GO:0007283

GO:0008092

GO:0008277

GO:0009898

GO:0009968

GO:0010519

GO:0010614

GO:0010855

GO:0010976

GO:0016787

GO:0017148

GO:0022414

GO:0030154

GO:0043226

GO:0043407

GO:0045471

GO:0045744

GO:0048487

GO:0050873

GO:0055119

GO:0060087

GO:0060135

GO:0060452

GO:0061052

GO:0071877

GO:0098772

GO:1900924

HMNXSV003048210

ILMN_2197365

L13391_at

PH_hs_0004554

TC01001624.hg

g4506516_3p_at

Participates

as a member of

Inferred To

rgs-10 [plasma membrane] (Caenorhabditis elegans)

rgs-6 [plasma membrane] (Caenorhabditis elegans)

SST2 [plasma membrane] (Saccharomyces cerevisiae)

rgs-3 [plasma membrane] (Caenorhabditis elegans)

RGS2 [plasma membrane] (Bos taurus)

RGS2 [plasma membrane] (Canis familiaris)

RGS2 [plasma membrane] (Dictyostelium discoideum)

RGS2 [plasma membrane] (Gallus gallus)

RGS2 [plasma membrane] (Saccharomyces cerevisiae)

RGS2 [plasma membrane] (Sus scrofa)

rgs1 [plasma membrane] (Schizosaccharomyces pombe)

rgs-8.1 [plasma membrane] (Caenorhabditis elegans)

Rgs2 [plasma membrane] (Mus musculus)

Rgs2 [plasma membrane] (Rattus norvegicus)

rgs-11 [plasma membrane] (Caenorhabditis elegans)

rgs-4 [plasma membrane] (Caenorhabditis elegans)

Homologues of RGS2 [plasma membrane] (Caenorhabditis elegans)

Homologues of RGS2 [plasma membrane] (Dictyostelium discoideum)

Homologues of RGS2 [plasma membrane] (Saccharomyces cerevisiae)

rgs-7 [plasma membrane] (Caenorhabditis elegans)

rgs2 [plasma membrane] (Xenopus tropicalis)

rgs-9 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

2808

ENSEMBL

ENSP00000235382, ENST00000235382

OpenTargets

ENSG00000116741

HPA

ENSG00000116741-RGS2

PRO

P41220

Pharos - Targets

P41220

PDB

4EKD, 2V4Z, 2AF0, 4EKC

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.571	6
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.553	2
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.553	2
UniProt:Q9P244 LRFN1	1	SALM2 [plasma membrane] (R-HSA-204734)	0.553	2
UniProt:O60260 PARK2	4	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) p-S65-PRKN [cytosol] (R-HSA-9834954) PRKN [cytosol] (R-HSA-201579)	0.553	2
UniProt:Q9Y2I6 NINL	2	p-NINL [cytosol] (R-HSA-380716) NINL [cytosol] (R-HSA-380706)	0.547	2

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